Evidence mapPaperPMID 36986438Full record

ReviewPharmaceuticals (Basel, Switzerland)2023

N-/T-Type vs. L-Type Calcium Channel Blocker in Treating Chronic Kidney Disease: A Systematic Review and Meta-Analysis.

Mingming Zhao, Ziyan Zhang, Zhiyu Pan, Sijia Ma, Meiying Chang, Jiao Fan, Shunxuan Xue, Yuejun Wang, Hua Qu, Yu Zhang

Open access · goldAbstract readReview
In one paragraph

Review in Pharmaceuticals (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.5field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Blood Pressure Management Strategies and Podocyte Health.American journal of hypertension · 2025
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Mingming ZhaoDepartment of Nephrology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China.ORCID 0000-0001-5513-1305
Ziyan ZhangDepartment of Nephrology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China.
Zhiyu PanDepartment of Nephrology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China.
Sijia MaDepartment of Nephrology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China.ORCID 0000-0001-9775-0294
Meiying ChangDepartment of Nephrology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China.
Jiao FanDepartment of Nephrology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China.
Shunxuan XueDepartment of Nephrology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China.
Yuejun WangDepartment of Geriatrics, Zhejiang Aged Care Hospital, Hangzhou Normal University, Hangzhou 310015, China.ORCID 0000-0002-4336-0255
Hua QuXiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China.
Yu ZhangDepartment of Nephrology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China.
Chinese Academy of Medical Sciences & Peking Union Medical College · CNBeijing University of Chinese Medicine · CNAffiliated Hospital of Hangzhou Normal University · CN

Funding

Capital Health Research and Development of Special 2018-2-4173Fundamental Research Funds for the Central public welfare research institutes ZZ11-023National Natural Science Foundation of China 81873300the Beijing Municipal of Science and Technology Major Project Z191100006619063
6 · The paper itself

Abstract

Renin-angiotensin system (RAS) inhibitors and calcium channel blockers (CCB) are often used together in chronic kidney disease (CKD). The PubMed, EMBASE, and Cochrane Library databases were searched to identify randomized controlled trials (RCTs) in order to explore better subtypes of CCB for the treatment of CKD. This meta-analysis of 12 RCTs with 967 CKD patients who were treated with RAS inhibitors demonstrated that, when compared with L-type CCB, N-/T-type CCB was superior in reducing urine albumin/protein excretion (SMD, -0.41; 95% CI, -0.64 to -0.18;

Indexed as

chronic kidney diseaseL-type calcium channel blockerN-type calcium channel blockerproteinuriaT-type calcium channel blocker

Identifiers

PMID36986438
PMCPMC10053533
OpenAlexW4321598651

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.