Evidence map›Paper›PMID 36986576›Full record

ReviewPharmaceutics2023

Silver Nanoparticles and Their Therapeutic Applications in Endodontics: A Narrative Review.

Farzaneh Afkhami, Parisa Forghan, James L Gutmann, Anil Kishen

Abstract readReview
In one paragraph

Review in Pharmaceutics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

  1. Article
  2. Green-SynthesizedJournal of functional biomaterials · 2026
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  4. Review
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  15. Review
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  17. Medicine and pharmacy reports · 2024
    Article
  18. Review
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  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Farzaneh AfkhamiDepartment of Endodontics, School of Dentistry, Tehran University of Medical Sciences, Tehran 1439955991, Iran.ORCID 0000-0002-7678-5313
Parisa ForghanSchool of Dentistry, Tehran University of Medical Sciences, Tehran 1894787545, Iran.ORCID 0000-0002-8428-0227
James L GutmannDepartment of Endodontics, College of Dentistry, Texas A&M University, Dallas, TX 75246, USA.
Anil KishenFaculty of Dentistry, University of Toronto, Toronto, ON M5G 1G6, Canada.ORCID 0000-0002-6953-2633

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The efficient elimination of microorganisms and their byproducts from infected root canals is compromised by the limitations in conventional root canal disinfection strategies and antimicrobials. Silver nanoparticles (AgNPs) are advantageous for root canal disinfection, mainly due to their wide-spectrum anti-microbial activity. Compared to other commonly used nanoparticulate antibacterials, AgNPs have acceptable antibacterial properties and relatively low cytotoxicity. Owing to their nano-scale, AgNPs penetrate deeper into the complexities of the root canal systems and dentinal tubules, as well as enhancing the antibacterial properties of endodontic irrigants and sealers. AgNPs gradually increase the dentin hardness in endodontically treated teeth and promote antibacterial properties when used as a carrier for intracanal medication. The unique properties of AgNPs make them an ideal additive for different endodontic biomaterials. However, the possible side effects of AgNPs, such as cytotoxicity and tooth discoloration potential, merits further research.

Indexed as

endodonticsmetal nanoparticlesnanoparticlesroot canal therapysilver nanoparticles

Identifiers

PMID36986576
PMCPMC10052550

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.