Evidence map›Paper›PMID 36986782›Full record

ArticlePharmaceutics2023

Cataleptogenic Effect of Haloperidol Formulated in Water-Soluble Calixarene-Based Nanoparticles.

Nadezda E Kashapova, Ruslan R Kashapov, Albina Y Ziganshina, Dmitry O Nikitin, Irina I Semina, Vadim V Salnikov, Vitaliy V Khutoryanskiy, Rouslan I Moustafine, Lucia Y Zakharova

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceutics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
1.0field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 7 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Nadezda E KashapovaArbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of RAS, 8 Arbuzov Str., 420088 Kazan, Russia.
Ruslan R KashapovArbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of RAS, 8 Arbuzov Str., 420088 Kazan, Russia.ORCID 0000-0002-8019-353X
Albina Y ZiganshinaArbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of RAS, 8 Arbuzov Str., 420088 Kazan, Russia.ORCID 0000-0003-4507-9923
Dmitry O NikitinDepartment of Pharmacology, Kazan State Medical University, 49 Butlerov Str., 420012 Kazan, Russia.
Irina I SeminaDepartment of Pharmacology, Kazan State Medical University, 49 Butlerov Str., 420012 Kazan, Russia.
Vadim V SalnikovKazan Institute of Biochemistry and Biophysics, FRC Kazan Scientific Center of RAS, 2/31 Lobachevsky Str., 420111 Kazan, Russia.
Vitaliy V KhutoryanskiySchool of Pharmacy, University of Reading, Whiteknights, Reading RG6 6DX, UK.ORCID 0000-0002-7221-2630
Rouslan I MoustafineInstitute of Pharmacy, Kazan State Medical University, 16 Fatykh Amirkhan Str., 420126 Kazan, Russia.ORCID 0000-0002-0916-2853
Lucia Y ZakharovaArbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of RAS, 8 Arbuzov Str., 420088 Kazan, Russia.
A.E. Arbuzov Institute of Organic and Physical Chemistry · RUKazan State Medical University · RUKazan Institute of Biochemistry and Biophysics · RUUniversity of Reading · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this study, a water-soluble form of haloperidol was obtained by coaggregation with calix[4]resorcinol bearing viologen groups on the upper rim and decyl chains on the lower rim to form vesicular nanoparticles. The formation of nanoparticles is achieved by the spontaneous loading of haloperidol into the hydrophobic domains of aggregates based on this macrocycle. The mucoadhesive and thermosensitive properties of calix[4]resorcinol-haloperidol nanoparticles were established by UV-, fluorescence and CD spectroscopy data. Pharmacological studies have revealed low in vivo toxicity of pure calix[4]resorcinol (LD

Indexed as

calixarenecatalepsyhaloperidolmucoadhesionnanoparticlesopen fieldself-assemblyTEMtoxicity in vivo

Identifiers

PMID36986782
PMCPMC10059056
OpenAlexW4324057254

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.