Evidence map›Paper›PMID 36988414›Full record

ArticleAdvanced biology2023

VEGFA Promotes Skeletal Muscle Regeneration in Aging.

Yori Endo, Charles D Hwang, Yuteng Zhang, Shayan Olumi, Daniel J Koh, Christina Zhu, Ronald L Neppl, Shailesh Agarwal, Indranil Sinha

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Yori EndoDivision of Plastic and Reconstructive Surgery, Department of Surgery, Brigham and Women's Hospital, Harvard University, Boston, MA, 02115, USA.ORCID 0000-0002-9282-8811
Charles D HwangDivision of Plastic and Reconstructive Surgery, Department of Surgery, Brigham and Women's Hospital, Harvard University, Boston, MA, 02115, USA.
Yuteng ZhangDivision of Plastic and Reconstructive Surgery, Department of Surgery, Brigham and Women's Hospital, Harvard University, Boston, MA, 02115, USA.
Shayan OlumiDivision of Plastic and Reconstructive Surgery, Department of Surgery, Brigham and Women's Hospital, Harvard University, Boston, MA, 02115, USA.
Daniel J KohDivision of Plastic and Reconstructive Surgery, Department of Surgery, Brigham and Women's Hospital, Harvard University, Boston, MA, 02115, USA.
Christina ZhuDivision of Plastic and Reconstructive Surgery, Department of Surgery, Brigham and Women's Hospital, Harvard University, Boston, MA, 02115, USA.
Ronald L NepplDepartment of Orthopedic Surgery, Brigham and Women's Hospital, Harvard University, Boston, MA, 02114, USA.
Shailesh AgarwalDivision of Plastic and Reconstructive Surgery, Department of Surgery, Brigham and Women's Hospital, Harvard University, Boston, MA, 02115, USA.
Indranil SinhaDivision of Plastic and Reconstructive Surgery, Department of Surgery, Brigham and Women's Hospital, Harvard University, Boston, MA, 02115, USA.ORCID 0000-0001-9494-6523
Brigham and Women's Hospital · US

Funding

Research EducationP30AG031679 · BRIGHAM AND WOMEN'S HOSPITAL · 2025 to 2025
$1.4M
NIA NIH HHS K76 AG059996NIA NIH HHS K76AG059996NIA NIH HHS P30 AG031679
6 · The paper itself

Abstract

Aging is associated with loss of skeletal muscle regeneration. Differentially regulated vascular endothelial growth factor (VEGF)A with aging may partially underlies this loss of regenerative capacity. To assess the role of VEGFA in muscle regeneration, young (12-14 weeks old) and old C57BL/6 mice (24,25 months old) are subjected to cryoinjury in the tibialis anterior (TA) muscle to induce muscle regeneration. The average cross-sectional area (CSA) of regenerating myofibers is 33% smaller in old as compared to young (p < 0.01) mice, which correlates with a two-fold loss of muscle VEGFA protein levels (p = 0.02). The capillary density in the TA is similar between the two groups. Young VEGF

Indexed as

Muscle, SkeletalVascular Endothelial Growth Factor AAgingAnimalsMiceMice, Inbred C57BLRegenerationVascular Endothelial Growth FactorsVascular Endothelial Growth Factor Avascular endothelial growth factor A, mouseVascular Endothelial Growth Factorsaginghypoxia signalingmuscle regenerationsarcopenia

Identifiers

PMID36988414
PMCPMC10539483
OpenAlexW4361297027

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.