Evidence map›Paper›PMID 36988705›Full record

ArticleCell and tissue research2023

Src inhibition induces mitotic arrest associated with chromosomal passenger complex.

Song Yang, Youguang Luo, Mulin Yang, Hua Ni, Hanxiao Yin, Ming Hu, Min Liu, Jun Zhou, Yunfan Yang, Dengwen Li

Abstract read
PubMed Publisher
In one paragraph

Article in Cell and tissue research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Cell proliferation and differentiation during epidermis renewal.Journal of Zhejiang University. Science. B · 2026
    Review
  2. Article
  3. UFMylation Modulates OFIP Stability and Centrosomal Localization.Journal of clinical laboratory analysis · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Song YangDepartment of Cell Biology School of Basic Medical Sciences Cheeloo College of Medicine, Shandong University, Jinan, China.
Youguang LuoState Key Laboratory of Medicinal Chemical Biology, Haihe Laboratory of Cell Ecosystem, College of Life Sciences, Nankai University, Tianjin, China. guang.luo@163.com.
Mulin YangState Key Laboratory of Medicinal Chemical Biology, Haihe Laboratory of Cell Ecosystem, College of Life Sciences, Nankai University, Tianjin, China.
Hua NiState Key Laboratory of Medicinal Chemical Biology, Haihe Laboratory of Cell Ecosystem, College of Life Sciences, Nankai University, Tianjin, China.
Hanxiao YinState Key Laboratory of Medicinal Chemical Biology, Haihe Laboratory of Cell Ecosystem, College of Life Sciences, Nankai University, Tianjin, China.
Ming HuDepartment of Otorhinolaryngology Head and Neck Surgery, Tianjin First Central Hospital, Tianjin, China.
Min LiuCenter for Cell Structure and Function, Shandong Provincial Key Laboratory of Animal Resistance Biology, College of Life Sciences, Collaborative Innovation Center of Cell Biology, Universities of Shandong, Shandong Normal University, Jinan, China.
Jun ZhouState Key Laboratory of Medicinal Chemical Biology, Haihe Laboratory of Cell Ecosystem, College of Life Sciences, Nankai University, Tianjin, China.
Yunfan YangDepartment of Cell Biology School of Basic Medical Sciences Cheeloo College of Medicine, Shandong University, Jinan, China.
Dengwen LiState Key Laboratory of Medicinal Chemical Biology, Haihe Laboratory of Cell Ecosystem, College of Life Sciences, Nankai University, Tianjin, China. dwli@nankai.edu.cn.ORCID http://orcid.org/0000-0002-4573-7191
Nankai University · CNShandong University · CNShandong Normal University · CNTianjin First Center Hospital · CN

Funding

National Key R&D Program of China 2021YFA1101001National Natural Science Foundation of China 32000870National Natural Science Foundation of China 32070787Postdoctoral Research Foundation of China 2022M711923Science and Technology Fund of Tianjin First Central Hospital 2020CM03Tianjin Health Science and technology project ZC20061
6 · The paper itself

Abstract

The non-receptor tyrosine kinase Src plays a key role in cell division, migration, adhesion, and survival. Src is overactivated in several cancers, where it transmits signals that promote cell survival, mitosis, and other important cancer hallmarks. Src is therefore a promising target in cancer therapy, but the underlying mechanisms are still uncertain. Here we show that Src is highly conserved across different species. Src expression increases during mitosis and is localized to the chromosomal passenger complex. Knockdown or inhibition of Src induces multipolar spindle formation, resulting in abnormal expression of the Aurora B and INCENP components of the chromosomal passenger complex. Molecular mechanism studies have found that Src interacts with and phosphorylates INCENP. This then leads to incorrect chromosome arrangement and segregation, resulting in cell division failure. Herein, Src and chromosomal passenger complex co-localize and Src inhibition impedes mitotic progression by inducing multipolar spindle formation. These findings provide novel insights into the molecular basis for using Src inhibitors to treat cancer.

Indexed as

Antineoplastic AgentsGenes, srcMitosisProto-Oncogene Proteins pp60(c-src)Chromosomal Proteins, Non-HistoneChromosomesCytoskeletonHumansSpindle ApparatusAntineoplastic AgentsChromosomal Proteins, Non-HistoneProto-Oncogene Proteins pp60(c-src)Chromosomal passenger complexMitosisMultipolar spindleSrc

Identifiers

PMID36988705
OpenAlexW4361289295

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.