Evidence map›Paper›PMID 36988886›Full record

ReviewAdvances in experimental medicine and biology2023

Roles of Cholesterol and PtdIns(4,5)P

Jonathan Pacheco, A Bohórquez-Hernández, Kevin M Méndez-Acevedo, Alicia Sampieri, Luis Vaca

Open access · bronzeAbstract readReview
PubMed Publisher
In one paragraph

Review in Advances in experimental medicine and biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.7field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 4 countries.

Jonathan PachecoDepartment of Pharmacology and Chemical Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
A Bohórquez-HernándezDepartment of Cell Biology, The Hospital for Sick Children, Toronto, ON, Canada.
Kevin M Méndez-AcevedoMax Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.
Alicia SampieriDepartamento de Biología Celular y del Desarrollo, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, México City, México.
Luis VacaDepartamento de Biología Celular y del Desarrollo, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, México City, México. lvaca@ifc.unam.mx.
Universidad Nacional Autónoma de México · MXHospital for Sick Children · CAMax Delbrück Center · DEUniversity of Pittsburgh · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Calcium is one of the most prominent second messengers. It is involved in a wide range of functions at the single-cell level but also in modulating regulatory mechanisms in the entire organism. One process mediating calcium signaling involves hydrolysis of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P

Indexed as

Phosphatidylinositol 4,5-DiphosphatePhosphatidylinositolsCalciumCalcium SignalingCell MembraneCholesterolORAI1 ProteinStromal Interaction Molecule 1CalciumCholesterolORAI1 ProteinPhosphatidylinositol 4,5-DiphosphatePhosphatidylinositolsStromal Interaction Molecule 1CholesterolER–PM junctionsOrai1PtdIns(4,5)P2SOCESTIM1

Identifiers

PMID36988886
OpenAlexW4361305492

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.