Evidence map›Paper›PMID 36989121›Full record

ArticleEpigenetics2023

Phenotypic and transcriptomic impact of expressing mammalian TET2 in the

Joy N Ismail, Sarah Mantash, Mohammad Hallal, Nada Jabado, Pierre Khoueiry, Margret Shirinian

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Epigenetics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Joy N IsmailDepartment of Experimental pathology, Immunology and Microbiology, Faculty of Medicine, American University of Beirut, Beirut, Lebanon.
Sarah MantashDepartment of Experimental pathology, Immunology and Microbiology, Faculty of Medicine, American University of Beirut, Beirut, Lebanon.
Mohammad HallalDepartment of Biochemistry and Molecular Genetics, Faculty of Medicine, American University of Beirut, Beirut, Lebanon.
Nada JabadoDepartment of Human Genetics, McGill University, Montreal, Quebec, Canada.
Pierre KhoueiryDepartment of Biochemistry and Molecular Genetics, Faculty of Medicine, American University of Beirut, Beirut, Lebanon.
Margret ShirinianDepartment of Experimental pathology, Immunology and Microbiology, Faculty of Medicine, American University of Beirut, Beirut, Lebanon.ORCID 0000-0003-4666-2758
American University of Beirut · LBMcGill University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ten-Eleven Translocation (TET) proteins have recently come to light as important epigenetic regulators conserved in multicellular organisms. TET knockdown studies in rodents have highlighted the critical role of these proteins for proper brain development and function. Mutations in mammalian mTET proteins and mTET2 specifically are frequent and deregulated in leukaemia and glioma respectively. Accordingly, we examined the role of mTET2 in tumorigenesis in larval haemocytes and adult heads in

Indexed as

Drosophila melanogasterDrosophila ProteinsAnimalsCircadian RhythmDioxygenasesDNA-Binding ProteinsDNA MethylationGene Expression ProfilingMammalsMutationTranscriptomeDioxygenasesDNA-Binding ProteinsDrosophila Proteinsbehaviourcircadian rhythmDrosophila melanogastergliomainnate immunityleukaemiaTET2

Identifiers

PMID36989121
PMCPMC10072067
OpenAlexW4361299200

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.