ArticleScientific reports2023
Mendelian randomization analyses reveal causal relationships between the human microbiome and longevity.
Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Bridging the gap:Gut microbes · 2026Review
- A Two-Sample Mendelian Randomisation Analysis of the Oral Microbiome and Oral/Oropharyngeal/Tongue Cancers.Oral health & preventive dentistry · 2026Article
- Maternal and infant gut microbiome.iMeta · 2026Review
- The Great Bustard (Ecology and evolution · 2026Article
- Mapping the canine gut microbiome: insights from the Dog Aging Project.Nature communications · 2026Article
- Article
- Examination of shared gut microbiome signatures in aging and Parkinson's disease.Frontiers in aging neuroscience · 2026Review
- Article
- Diagnostic potential of salivary microbiota in persistent pulmonary nodules: identifying biomarkers and functional pathways using 16S rRNA sequencing and machine learning.Journal of translational medicine · 2024Article
- Associations Among Estrogens, the Gut Microbiome and Osteoporosis.Current osteoporosis reports · 2024Review
- Mendelian randomization analyses support causal relationships between gut microbiome and longevity.Journal of translational medicine · 2024Article
- Causal effects of denture wearing on epigenetic age acceleration and the mediating pathways: a mendelian randomization study.BMC oral health · 2024Article
- Investigating the causal relationship between thyroid dysfunction diseases and osteoporosis: a two-sample Mendelian randomization analysis.Scientific reports · 2024Article
- Aging Gut Microbiome in Healthy and Unhealthy Aging.Aging and disease · 2024Review
- Article
- A study on the causal relationship between the gut microbiome and herpes zoster using Mendelian randomization.Frontiers in medicine · 2024Article
- Genetic insights into the association of statin and newer nonstatin drug target genes with human longevity: a Mendelian randomization analysis.Lipids in health and disease · 2023Article
- Causal effect between gut microbiota and pancreatic cancer: a two-sample Mendelian randomization study.BMC cancer · 2023Article
- Causal effect of gut microbiota on DNA methylation phenotypic age acceleration: a two-sample Mendelian randomization study.Scientific reports · 2023Article
- Causal analysis of the gut microbiota in differentiated thyroid carcinoma: a two-sample Mendelian randomization study.Frontiers in genetics · 2023Article
Corrections and comments
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Authors and funding
15 authors.
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Abstract
Although recent studies have revealed the association between the human microbiome especially gut microbiota and longevity, their causality remains unclear. Here, we assess the causal relationships between the human microbiome (gut and oral microbiota) and longevity, by leveraging bidirectional two-sample Mendelian randomization (MR) analyses based on genome-wide association studies (GWAS) summary statistics of the gut and oral microbiome from the 4D-SZ cohort and longevity from the CLHLS cohort. We found that some disease-protected gut microbiota such as Coriobacteriaceae and Oxalobacter as well as the probiotic Lactobacillus amylovorus were related to increased odds of longevity, whereas the other gut microbiota such as colorectal cancer pathogen Fusobacterium nucleatum, Coprococcus, Streptococcus, Lactobacillus, and Neisseria were negatively associated with longevity. The reverse MR analysis further revealed genetically longevous individuals tended to have higher abundances of Prevotella and Paraprevotella but lower abundances of Bacteroides and Fusobacterium species. Few overlaps of gut microbiota-longevity interactions were identified across different populations. We also identified abundant links between the oral microbiome and longevity. The additional analysis suggested that centenarians genetically had a lower gut microbial diversity, but no difference in oral microbiota. Our findings strongly implicate these bacteria to play a role in human longevity and underscore the relocation of commensal microbes among different body sites that would need to be monitored for long and healthy life.
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