Evidence map›Paper›PMID 36992151›Full record

ArticleVaccines2023

Heart Rate Variability in Subjects with Severe Allergic Background Undergoing COVID-19 Vaccination.

Maria Bernadette Cilona, Filippo D'Amico, Chiara Asperti, Giuseppe Alvise Ramirez, Stefano Turi, Giovanni Benanti, Shai Marc Bohane, Serena Nannipieri, Rosa Labanca, Matteo Gervasini and 6 more

Abstract read
In one paragraph

Article in Vaccines, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Maria Bernadette CilonaUnit of Immunology, Rheumatology, Allergy and Rare Diseases, IRCCS San Raffaele Scientific Institute, IRCSS San Raffaele Hospital, Via Olgettina, 60, 21132 Milan, Italy.ORCID 0000-0003-3677-4342
Filippo D'AmicoDepartment of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, 21132 Milan, Italy.ORCID 0000-0002-4594-0659
Chiara AspertiUnit of Immunology, Rheumatology, Allergy and Rare Diseases, IRCCS San Raffaele Scientific Institute, IRCSS San Raffaele Hospital, Via Olgettina, 60, 21132 Milan, Italy.
Giuseppe Alvise RamirezUnit of Immunology, Rheumatology, Allergy and Rare Diseases, IRCCS San Raffaele Scientific Institute, IRCSS San Raffaele Hospital, Via Olgettina, 60, 21132 Milan, Italy.ORCID 0000-0002-2889-366X
Stefano TuriDepartment of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, 21132 Milan, Italy.ORCID 0000-0001-7365-3510
Giovanni BenantiUnit of Immunology, Rheumatology, Allergy and Rare Diseases, IRCCS San Raffaele Scientific Institute, IRCSS San Raffaele Hospital, Via Olgettina, 60, 21132 Milan, Italy.ORCID 0000-0002-4310-6951
Shai Marc BohaneDepartment of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, 21132 Milan, Italy.
Serena NannipieriUnit of Immunology, Rheumatology, Allergy and Rare Diseases, IRCCS San Raffaele Scientific Institute, IRCSS San Raffaele Hospital, Via Olgettina, 60, 21132 Milan, Italy.
Rosa LabancaDepartment of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, 21132 Milan, Italy.ORCID 0000-0002-1139-9585
Matteo GervasiniDepartment of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, 21132 Milan, Italy.
Federica RussettiDepartment of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, 21132 Milan, Italy.
Naomi ViapianaUnit of Immunology, Rheumatology, Allergy and Rare Diseases, IRCCS San Raffaele Scientific Institute, IRCSS San Raffaele Hospital, Via Olgettina, 60, 21132 Milan, Italy.ORCID 0000-0003-4532-6621
Martina LezziDepartment of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, 21132 Milan, Italy.
Giovanni LandoniDepartment of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, 21132 Milan, Italy.ORCID 0000-0002-8594-5980
Lorenzo DagnaUnit of Immunology, Rheumatology, Allergy and Rare Diseases, IRCCS San Raffaele Scientific Institute, IRCSS San Raffaele Hospital, Via Olgettina, 60, 21132 Milan, Italy.
Mona-Rita YacoubUnit of Immunology, Rheumatology, Allergy and Rare Diseases, IRCCS San Raffaele Scientific Institute, IRCSS San Raffaele Hospital, Via Olgettina, 60, 21132 Milan, Italy.ORCID 0000-0003-2417-0410

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Anti-Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) vaccination is the world's most important strategy for stopping the pandemic. Vaccination challenges the body's immune response and can be complicated by hypersensitivity reactions. The autonomic nervous system can modulate the inflammatory immune response, therefore constituting a potential marker to characterize individuals at high risk of hypersensitivity reactions. Autonomic nervous system functionality was assessed through measurement of the heart rate variability (HRV) in subjects with a history of severe allergic reactions and 12 control subjects. HRV parameters included the mean electrocardiograph RR interval and the standard deviation of all normal R-R intervals (SDNN). All measurements were performed immediately before the anti-SARS-CoV-2 vaccination. The median RR variability was lower in the study than in the control group: 687 ms (645-759) vs. 821 ms (759-902);

Indexed as

autonomic nervous systemCOVID-19heart rate variabilityhypersensitivity reactionsSARS-CoV-2vaccination

Identifiers

PMID36992151
PMCPMC10051914

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.