Evidence map›Paper›PMID 36992419›Full record

ArticleViruses2023

Pregnancy Is Associated with Impaired Transcription of Human Endogenous Retroviruses and of TRIM28 and SETDB1, Particularly in Mothers Affected by Multiple Sclerosis.

Pier-Angelo Tovo, Luca Marozio, Giancarlo Abbona, Cristina Calvi, Federica Frezet, Stefano Gambarino, Maddalena Dini, Chiara Benedetto, Ilaria Galliano, Massimiliano Bergallo

Open access · goldFull text read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. KAP1 in antiviral immunity: dual roles in viral silencing and immune regulation.Frontiers in cellular and infection microbiology · 2025
    Review
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Pier-Angelo TovoDepartment of Public Health and Pediatric Sciences, University of Turin, 10126 Turin, Italy.
Luca MarozioDepartment of Surgical Sciences, Obstetrics and Gynecology 1, University of Turin, 10126 Turin, Italy.ORCID 0000-0002-9617-5301
Giancarlo AbbonaPathology Unit, Department Laboratory Medicine, AOU Città della Salute e della Scienza di Torino, 10126 Turin, Italy.
Cristina CalviDepartment of Public Health and Pediatric Sciences, University of Turin, 10126 Turin, Italy.
Federica FrezetDepartment of Surgical Sciences, Obstetrics and Gynecology 1, University of Turin, 10126 Turin, Italy.
Stefano GambarinoPediatric Laboratory, Department of Public Health and Pediatric Sciences, University of Turin, 10126 Turin, Italy.
Maddalena DiniPediatric Laboratory, Department of Public Health and Pediatric Sciences, University of Turin, 10126 Turin, Italy.
Chiara BenedettoDepartment of Surgical Sciences, Obstetrics and Gynecology 1, University of Turin, 10126 Turin, Italy.
Ilaria GallianoDepartment of Public Health and Pediatric Sciences, University of Turin, 10126 Turin, Italy.
Massimiliano BergalloDepartment of Public Health and Pediatric Sciences, University of Turin, 10126 Turin, Italy.
University of Turin · ITAzienda Ospedaliera Citta' della Salute e della Scienza di Torino · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Accumulating evidence highlights the pathogenetic role of human endogenous retroviruses (HERVs) in eliciting and maintaining multiple sclerosis (MS). Epigenetic mechanisms, such as those regulated by TRIM 28 and SETDB1, are implicated in HERV activation and in neuroinflammatory disorders, including MS. Pregnancy markedly improves the course of MS, but no study explored the expressions of HERVs and of TRIM28 and SETDB1 during gestation. Using a polymerase chain reaction real-time Taqman amplification assay, we assessed and compared the transcriptional levels of

Indexed as

Endogenous RetrovirusesHistone-Lysine N-MethyltransferaseMultiple SclerosisPregnancy ComplicationsTripartite Motif-Containing Protein 28Epigenesis, GeneticFemaleGenes, envHumansInfant, NewbornMothersPregnancyRNA, MessengerHistone-Lysine N-MethyltransferaseRNA, MessengerSETDB1 protein, humanTRIM28 protein, humanTripartite Motif-Containing Protein 28human endogenous retrovirusesmultiple sclerosispregnancySETDB1TRIM28

Identifiers

PMID36992419
PMCPMC10051116
OpenAlexW4323664216

What Socratic holds

Textfull text, public
LicenceCC BY
measurements read19
identifiers read1
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.