Evidence map›Paper›PMID 36992501›Full record

ArticleViruses2023

Correlation of SARS-CoV-2 Neutralization with Antibody Levels in Vaccinated Individuals.

Shazeda Haque Chowdhury, Sean Riley, Riley Mikolajczyk, Lauren Smith, Lakshmanan Suresh, Amy Jacobs

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Shazeda Haque ChowdhuryDepartment of Microbiology and Immunology, State University of New York at Buffalo, Buffalo, NY 14213, USA.
Sean RileyDepartment of Microbiology and Immunology, State University of New York at Buffalo, Buffalo, NY 14213, USA.
Riley MikolajczykDepartment of Microbiology and Immunology, State University of New York at Buffalo, Buffalo, NY 14213, USA.
Lauren SmithDepartment of Microbiology and Immunology, State University of New York at Buffalo, Buffalo, NY 14213, USA.
Lakshmanan SureshDepartment of Oral Diagnostic Sciences, State University of New York at Buffalo, Buffalo, NY 14215, USA.ORCID 0000-0003-3894-1271
Amy JacobsDepartment of Microbiology and Immunology, State University of New York at Buffalo, Buffalo, NY 14213, USA.ORCID 0000-0002-1277-4471

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neutralizing antibody titers are an important measurement of the effectiveness of vaccination against SARS-CoV-2. Our laboratory has set out to further verify the functionality of these antibodies by measuring the neutralization capacity of patient samples against infectious SARS-CoV-2. Samples from patients from Western New York who had been vaccinated with the original Moderna and Pfizer vaccines (two doses) were tested for neutralization of both Delta (B.1.617.2) and Omicron (BA.5). Strong correlations between antibody levels and neutralization of the delta variant were attained; however, antibodies from the first two doses of the vaccines did not have good neutralization coverage of the subvariant omicron BA.5. Further studies are ongoing with local patient samples to determine correlation following updated booster administration.

Indexed as

COVID-19SARS-CoV-2AntibodiesAntibodies, NeutralizingAntibodies, ViralHumansLaboratoriesAntibodiesAntibodies, NeutralizingAntibodies, Viralantibody responseCOVID-19RNA virusesSARS-CoV-2

Identifiers

PMID36992501
PMCPMC10057460

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.