Evidence map›Paper›PMID 36993539›Full record

ArticlebioRxiv : the preprint server for biology2023

Remote neuronal activity drives glioma infiltration via Sema4f.

Emmet Huang-Hobbs, Yi-Ting Cheng, Yeunjung Ko, Estefania Luna-Figueroa, Brittney Lozzi, Kathryn R Taylor, Malcolm McDonald, Peihao He, Hsiao-Chi Chen, Yuhui Yang and 14 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

24 authors at 3 institutions in 1 country.

Emmet Huang-HobbsThe Integrative Molecular and Biomedical Sciences Graduate Program (IMBS), Baylor College of Medicine, Houston TX 77030.
Yi-Ting ChengCenter for Cell and Gene Therapy, Baylor College of Medicine, Houston TX 77030.
Yeunjung KoCenter for Cell and Gene Therapy, Baylor College of Medicine, Houston TX 77030.
Estefania Luna-FigueroaCenter for Cell and Gene Therapy, Baylor College of Medicine, Houston TX 77030.
Brittney LozziCenter for Cell and Gene Therapy, Baylor College of Medicine, Houston TX 77030.
Kathryn R TaylorDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.
Malcolm McDonaldCenter for Cell and Gene Therapy, Baylor College of Medicine, Houston TX 77030.
Peihao HeCenter for Cell and Gene Therapy, Baylor College of Medicine, Houston TX 77030.
Hsiao-Chi ChenCenter for Cell and Gene Therapy, Baylor College of Medicine, Houston TX 77030.
Yuhui YangDepartment of Neurosurgery, Baylor College of Medicine, Houston TX 77030.
Ehson MalekiCenter for Cell and Gene Therapy, Baylor College of Medicine, Houston TX 77030.
Zhung-Fu LeeCenter for Cell and Gene Therapy, Baylor College of Medicine, Houston TX 77030.
Sanjana MuraliCenter for Cell and Gene Therapy, Baylor College of Medicine, Houston TX 77030.
Michael WilliamsonCenter for Cell and Gene Therapy, Baylor College of Medicine, Houston TX 77030.
Dongjoo ChoiCenter for Cell and Gene Therapy, Baylor College of Medicine, Houston TX 77030.
Rachel CurryThe Integrative Molecular and Biomedical Sciences Graduate Program (IMBS), Baylor College of Medicine, Houston TX 77030.
James BayleyDepartment of Neurosurgery, Baylor College of Medicine, Houston TX 77030.
Junsung WooCenter for Cell and Gene Therapy, Baylor College of Medicine, Houston TX 77030.
Ali JalaliCenter for Cancer Neuroscience, Baylor College of Medicine, Houston, TX 77030.
Michelle MonjeDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.
Jeffrey L NoebelsDepartment of Human and Molecular Genetics, Baylor College of Medicine, Houston, TX, 77030.
Akdes Serin HarmanciCenter for Cancer Neuroscience, Baylor College of Medicine, Houston, TX 77030.
Ganesh RaoCenter for Cancer Neuroscience, Baylor College of Medicine, Houston, TX 77030.
Benjamin DeneenThe Integrative Molecular and Biomedical Sciences Graduate Program (IMBS), Baylor College of Medicine, Houston TX 77030.
Baylor College of Medicine · USHoward Hughes Medical Institute · USStanford University · US

Funding

Tumor BiologyP30CA125123 · NCI · BAYLOR COLLEGE OF MEDICINE · PI Suzanne AW Fuqua · 2007 to 2026
$73.9M
VISION RESEARCH CENTERP30EY002520 · NEI · BAYLOR COLLEGE OF MEDICINE · PI Samuel M Wu · 1985 to 2026
$14.8M
Preclinical and Clincial OutcomesP50HD103555 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI Sandesh Chakravarthy Sreenath Nagamani, David Loren Nelson · 2020 to 2026
$9.9M
Training In Cell and Gene TherapyT32HL092332 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI MALCOLM K. BRENNER, Bruno Di Stefano · 2008 to 2026
$6.9M
Glioma Circuitry: Bridging Systems Neuroscience and CancerDP1NS111132 · NINDS · STANFORD UNIVERSITY · PI MONJE-DEISSEROTH, MICHELLE · 2018 to 2022
$5.7M
Transcriptional regulation of gliogenesis in the CNSR01NS071153 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI DENEEN, BENJAMIN · 2010 to 2022
$5.0M
Integrative bioinformatics and functional characterization of oncogenic driver aberrations in cancerU01CA217842 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI DENEEN, BENJAMIN, MILLS, GORDON B. · 2017 to 2021
$3.6M
MOLECULAR DISSECTION OF SEIZURE MICROENVIRONMENT IN MALIGNANT GLIOMAR01CA223388 · NCI · BAYLOR COLLEGE OF MEDICINE · PI DENEEN, BENJAMIN, NOEBELS, JEFFREY · 2018 to 2022
$3.5M
Cellular and Molecular Mechanisms of GBM InfiltrationR01NS124093 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI Benjamin Deneen, Ganesh Rao · 2022 to 2026
$1.6M
High Throughput Genomic Sequencer at BCM Core FacilityS10OD023469 · OD · BAYLOR COLLEGE OF MEDICINE · PI CHEN, RUI · 2017 to 2017
$600k
Defining invasion dynamics of GBM reveals axon guidance genes drive invasionF31CA243382 · NCI · BAYLOR COLLEGE OF MEDICINE · PI HUANG-HOBBS, EMMET JAMES EUGENE · 2019 to 2021
$128k
Acquisition of 10X Genomics Chromium Instrument to Accelerate Genomic and Single Cell Transcriptomic ResearchS10OD025240 · OD · BAYLOR COLLEGE OF MEDICINE · PI DODDAPANENI, HARSHA VARDHAN · 2018 to 2018
$125k
NCI NIH HHS F31 CA243382NCI NIH HHS F31 CA265156NCI NIH HHS P30 CA125123NCI NIH HHS R01 CA223388NCI NIH HHS U01 CA217842NEI NIH HHS P30 EY002520NHLBI NIH HHS T32 HL092332NICHD NIH HHS P50 HD103555NIH HHS S10 OD023469NIH HHS S10 OD025240NINDS NIH HHS DP1 NS111132NINDS NIH HHS R01 NS071153NINDS NIH HHS R01 NS124093
6 · The paper itself

Abstract

The tumor microenvironment (TME) plays an essential role in malignancy and neurons have emerged as a key component of the TME that promotes tumorigenesis across a host of cancers. Recent studies on glioblastoma (GBM) highlight bi-directional signaling between tumors and neurons that propagates a vicious cycle of proliferation, synaptic integration, and brain hyperactivity; however, the identity of neuronal subtypes and tumor subpopulations driving this phenomenon are incompletely understood. Here we show that callosal projection neurons located in the hemisphere contralateral to primary GBM tumors promote progression and widespread infiltration. Using this platform to examine GBM infiltration, we identified an activity dependent infiltrating population present at the leading edge of mouse and human tumors that is enriched for axon guidance genes. High-throughput,

Identifiers

PMID36993539
PMCPMC10055154
OpenAlexW4327860921

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.