Evidence map›Paper›PMID 36993570›Full record

ArticlebioRxiv : the preprint server for biology2023

Genipin Crosslinks the Extracellular Matrix to Rescue Developmental and Degenerative Defects, and Accelerates Regeneration of Peripheral Neurons.

Kenyi Saito-Diaz, Paula Dietrich, Hsueh-Fu Wu, Xin Sun, Archie Jayesh Patel, Camryn Gale Wzientek, Anthony Robert Prudden, Geert-Jan Boons, Shuibing Chen, Lorenz Studer and 3 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Kenyi Saito-DiazCenter for Molecular Medicine, University of Georgia, Athens GA, USA.
Paula DietrichDepartment of Physiology, The University of Tennessee, Health Science Center, Memphis, TN, USA.
Hsueh-Fu WuCenter for Molecular Medicine, University of Georgia, Athens GA, USA.
Xin SunCollege of Engineering, University of Georgia, Athens GA, USA.
Archie Jayesh PatelCenter for Molecular Medicine, University of Georgia, Athens GA, USA.
Camryn Gale WzientekComplex Carbohydrate Research Center, University of Georgia, Athens, GA, USA.
Anthony Robert PruddenComplex Carbohydrate Research Center, University of Georgia, Athens, GA, USA.
Geert-Jan BoonsComplex Carbohydrate Research Center, University of Georgia, Athens, GA, USA.
Shuibing ChenDepartment of Surgery and Department of Biochemistry at Weill Cornell Medical College, New York, NY, USA.
Lorenz StuderCenter for Stem Cell Biology, Sloan Kettering Institute, New York, NY, USA.
Bingqian XuCollege of Engineering, University of Georgia, Athens GA, USA.
Ioannis DragatsisDepartment of Physiology, The University of Tennessee, Health Science Center, Memphis, TN, USA.
Nadja ZeltnerCenter for Molecular Medicine, University of Georgia, Athens GA, USA.
University of Georgia · USUniversity of Tennessee Health Science Center · USCornell University · USKettering University · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
Precision Medicine for the Peripheral Nervous System Disorder Familiar DysautonomiaR01NS114567 · NINDS · UNIVERSITY OF GEORGIA · PI Nadja Zeltner · 2021 to 2026
$3.0M
NCI NIH HHS P30 CA008748NINDS NIH HHS R01 NS114567
6 · The paper itself

Abstract

The peripheral nervous system (PNS) is essential for proper body function. A high percentage of the population suffer nerve degeneration or peripheral damage. For example, over 40% of patients with diabetes or undergoing chemotherapy develop peripheral neuropathies. Despite this, there are major gaps in the knowledge of human PNS development and therefore, there are no available treatments. Familial Dysautonomia (FD) is a devastating disorder that specifically affects the PNS making it an ideal model to study PNS dysfunction. FD is caused by a homozygous point mutation in

Identifiers

PMID36993570
PMCPMC10055431
OpenAlexW4360822120

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.