Evidence map›Paper›PMID 36993624›Full record

ArticlebioRxiv : the preprint server for biology2023

Targeted repression of DNA topoisomerase I by CRISPRi reveals a critical function for it in the

Li Shen, Leiqiong Gao, Abigail R Swoboda, Scot P Ouellette

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Li ShenDepartment of Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences Center, New Orleans, LA 70112.
Leiqiong GaoDepartment of Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences Center, New Orleans, LA 70112.
Abigail R SwobodaDepartment of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Scot P OuelletteDepartment of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Louisiana State University Health Sciences Center New Orleans · USUniversity of Nebraska Medical Center · US

Funding

CRISPR interference of essential stage-specific gene function in Chlamydia trachomatisR21AI175651 · NIAID · LSU HEALTH SCIENCES CENTER · PI SHEN, LI · 2023 to 2024
$429k
Probing mechanism and outcome of Chlamydia trachomatis response to antimicrobial insultsR21AI146454 · NIAID · LSU HEALTH SCIENCES CENTER · PI SHEN, LI · 2019 to 2020
$404k
NIAID NIH HHS R21 AI146454NIAID NIH HHS R21 AI175651
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

antibacterial mechanismbacterial developmental cycleChlamydia trachomatisCRISPRidCas12DNA topoisomeraseDNA topologyquinoloneTopAtranscription

Identifiers

PMID36993624
PMCPMC10054935
OpenAlexW4324374547

What Socratic holds

Textmetadata
LicenceCC BY-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.