Evidence map›Paper›PMID 36993674›Full record

ArticlemedRxiv : the preprint server for health sciences2023

Alpha globin gene copy number and incident ischemic stroke risk among Black Americans.

A Parker Ruhl, Neal Jeffries, Yu Yang, Steven D Brooks, Rakhi P Naik, Lydia H Pecker, Bryan T Mott, Cheryl A Winkler, Nicole D Armstrong, Neil A Zakai and 7 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors at 7 institutions in 1 country.

A Parker RuhlLaboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
Neal JeffriesOffice of Biostatistics Research, National Heart, Lung, and Blood Institute, Bethesda, Maryland.
Yu YangDivision of Blood Diseases and Resources, National Heart, Lung, and Blood Institute, Rockville, Maryland.
Steven D BrooksLaboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
Rakhi P NaikDivision of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Lydia H PeckerDivision of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Bryan T MottWake Forest University School of Medicine, Winston-Salem, North Carolina.
Cheryl A WinklerBasic Research Laboratory, National Cancer Institute, Frederick National Laboratory for Cancer Research, Frederick, Maryland.
Nicole D ArmstrongDepartment of Epidemiology, University of Alabama at Birmingham, Birmingham, Alabama.
Neil A ZakaiDepartment of Medicine, Larner College of Medicine at the University of Vermont, Burlington, Vermont.
Orlando M GutierrezDepartment of Epidemiology, University of Alabama at Birmingham, Birmingham, Alabama.
Suzanne E JuddDepartment of Epidemiology, University of Alabama at Birmingham, Birmingham, Alabama.
Virginia J HowardDepartment of Epidemiology, University of Alabama at Birmingham, Birmingham, Alabama.
George HowardDepartment of Epidemiology, University of Alabama at Birmingham, Birmingham, Alabama.
Marguerite R IrvinDepartment of Epidemiology, University of Alabama at Birmingham, Birmingham, Alabama.
Mary CushmanDepartment of Medicine, Larner College of Medicine at the University of Vermont, Burlington, Vermont.
Hans C AckermanLaboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
University of Alabama at Birmingham · USNational Institutes of Health · USJohns Hopkins University · USNational Heart Lung and Blood Institute · USUniversity of Vermont · USFrederick National Laboratory for Cancer Research · USWake Forest University · US

Funding

VCID and Stroke in a Bi-racial National CohortU01NS041588 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CUSHMAN, MARY, HOWARD, GEORGE · 2002 to 2022
$96.0M
Regional & Racial Differences in Hemostasis & Risk of Stroke & Heart DiseaseK08HL096841 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI ZAKAI, NEIL ADRIAN · 2010 to 2014
$705k
NHLBI NIH HHS K08 HL096841NINDS NIH HHS U01 NS041588
6 · The paper itself

Abstract

Introduction: People with African ancestry have greater stroke risk and greater heritability of stroke risk than people of other ancestries. Given the importance of nitric oxide (NO) in stroke, and recent evidence that alpha globin restricts nitric oxide release from vascular endothelial cells, we hypothesized that alpha globin gene ( Methods: We evaluated 8,947 participants self-reporting African ancestry in the national, prospective Reasons for Geographic And Racial Differences in Stroke (REGARDS) cohort. Incident ischemic stroke was defined as non-hemorrhagic stroke with focal neurological deficit lasting ≥ 24 hours confirmed by the medical record or focal or non-focal neurological deficit with positive imaging confirmed with medical records. Genomic DNA was analyzed using droplet digital PCR to determine Results: Four-hundred seventy-nine (5.3%) participants had an incident ischemic stroke over a median (IQR) of 11.0 (5.7, 14.0) years' follow-up. Conclusions: Although a reduction in

Identifiers

PMID36993674
PMCPMC10055557
OpenAlexW4327861798

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.