Evidence map›Paper›PMID 36993944›Full record

ArticleBrain communications2023

Early blood neurofilament light chain and myelin oligodendrocyte glycoprotein antibody levels associate with different disease courses of myelin oligodendrocyte glycoprotein-associated disease in children.

Philippe Horellou, Lorraine Flet-Berliac, Carole Leroy, Laetitia Giorgi, Candie Joly, Delphine Desjardins, Pascale Chrétien, Salima Hacein-Bey-Abina, Roger Le Grand, Kumaran Deiva

Open access · goldFull text read
In one paragraph

Article in Brain communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Neuroglial markers of damage in autoimmune neurology.Therapeutic advances in neurological disorders · 2026
    Review
  3. Role of soluble biomarkers in treating multiple sclerosis and neuroinflammatory conditions.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
    Review
  4. Clinical use and reporting of neurofilament quantification in neurological disorders: A global overview.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Philippe HorellouCenter for Immunology of Viral, Auto-Immune, Hematological and Bacterial diseases (IMVA-HB/IDMIT), Université Paris-Saclay, CEA, INSERM, Le Kremlin Bicêtre 94276, France.ORCID https://orcid.org/0000-0003-2467-8177
Lorraine Flet-BerliacCenter for Immunology of Viral, Auto-Immune, Hematological and Bacterial diseases (IMVA-HB/IDMIT), Université Paris-Saclay, CEA, INSERM, Le Kremlin Bicêtre 94276, France.
Carole LeroyCenter for Immunology of Viral, Auto-Immune, Hematological and Bacterial diseases (IMVA-HB/IDMIT), Université Paris-Saclay, CEA, INSERM, Le Kremlin Bicêtre 94276, France.
Laetitia GiorgiCenter for Immunology of Viral, Auto-Immune, Hematological and Bacterial diseases (IMVA-HB/IDMIT), Université Paris-Saclay, CEA, INSERM, Le Kremlin Bicêtre 94276, France.
Candie JolyCenter for Immunology of Viral, Auto-Immune, Hematological and Bacterial diseases (IMVA-HB/IDMIT), Université Paris-Saclay, CEA, INSERM, Le Kremlin Bicêtre 94276, France.
Delphine DesjardinsCenter for Immunology of Viral, Auto-Immune, Hematological and Bacterial diseases (IMVA-HB/IDMIT), Université Paris-Saclay, CEA, INSERM, Le Kremlin Bicêtre 94276, France.
Pascale ChrétienClinical Immunology Laboratory, Groupe Hospitalier Universitaire Paris-Saclay, Hôpital Kremlin-Bicêtre, Assistance Publique-Hôpitaux de Paris, Le-Kremlin-Bicêtre 94275, France.
Salima Hacein-Bey-AbinaClinical Immunology Laboratory, Groupe Hospitalier Universitaire Paris-Saclay, Hôpital Kremlin-Bicêtre, Assistance Publique-Hôpitaux de Paris, Le-Kremlin-Bicêtre 94275, France.
Roger Le GrandCenter for Immunology of Viral, Auto-Immune, Hematological and Bacterial diseases (IMVA-HB/IDMIT), Université Paris-Saclay, CEA, INSERM, Le Kremlin Bicêtre 94276, France.
Kumaran DeivaCenter for Immunology of Viral, Auto-Immune, Hematological and Bacterial diseases (IMVA-HB/IDMIT), Université Paris-Saclay, CEA, INSERM, Le Kremlin Bicêtre 94276, France.
Inserm · FRCentre National de la Recherche Scientifique · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acquired demyelinating syndrome associated with myelin oligodendrocyte glycoprotein antibodies, named recently myelin oligodendrocyte glycoprotein-associated disease, represents >27% of this paediatric syndrome. Relapses occur in 40% of them, which may be associated with severe outcomes. Aiming to identify biomarker allowing to predict relapse, we measured both myelin oligodendrocyte glycoprotein antibodies and neurofilament light chain levels in blood samples of patients that are known to reflect axonal injuries in neurological diseases including demyelinating autoimmune disorders. Three groups of patients were selected: relapsing myelin oligodendrocyte glycoprotein-associated disease (

Indexed as

acquired demyelinating syndromesautoimmune diseasesmyelin oligodendrocyte glycoproteinneurofilamentneuroinflammation

Identifiers

PMID36993944
PMCPMC10042280
OpenAlexW4327752629

What Socratic holds

Textfull text, public
LicenceCC BY
measurements read36
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.