Evidence map›Paper›PMID 37000261›Full record

ReviewJournal of cancer research and clinical oncology2023

Molecular markers predicting the progression and prognosis of human papillomavirus-induced cervical lesions to cervical cancer.

Fatema Alzahraa Samy Amin, Zeba Un Naher, P Shaik Syed Ali

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of cancer research and clinical oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Fatema Alzahraa Samy AminSchool of Medicine, Maldives National University, Male', Maldives. fathema.alzahraa@mnu.edu.mv.
Zeba Un NaherSchool of Medicine, Maldives National University, Male', Maldives.
P Shaik Syed AliSchool of Medicine, Maldives National University, Male', Maldives.
Maldives National University · MV

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionPersistent Human Papillomavirus (HPV) infection is linked to 99% of cervical cancer (CC) cases. HPV types 16 and 18 alone result in 75% of CC cases and thus are considered to be high-risk types (HR-HPV). CC is the third most common cancer among women globally. Approximately, 7000 patients die from it yearly. It is worthy to note that not every patient with HPV precancerous lesions will progress to CC.

objectivesThe objectives of this review is to explore the utilization of molecular and viral biomarkers as a tool for early detection and prediction of HPV-induced cervical lesions that might progress to CC.

methodsThe data bases PubMed, Google Scholar, EBSCO were searched using keywords CC screening, HPV, and recent molecular biomarkers. The search time frame was within the last 7 years. Studies on HPV-induced cancers other than CC were excluded; a total of 200 eligible articles were retrieved.

resultsIn this review we explored the current literature about HPV virology, virulence genes and early diagnostic/prognostic molecular biomarkers in CC. The oncogenic property of HPV is attributed to viral expression of various early proteins (E5, E6, E7). The interaction between viral oncoproteins and the cellular genetic apparatus alters the expression of many genes at different phases of the disease. There was an association between cervical lesions induced by HR-HPV and the overexpression of markers of oxidative DNA damage and other proteins. The markers p16

conclusionAdding different the above markers to the CC screening program scheme might offer a triage for prioritizing patient management.

Indexed as

MicroRNAsOncogene Proteins, ViralPapillomavirus InfectionsUterine Cervical DysplasiaUterine Cervical NeoplasmsBiomarkers, TumorFemaleHuman Papillomavirus VirusesHumansPapillomaviridaePrognosisBiomarkers, TumorMicroRNAsMIRN377 microRNA, humanOncogene Proteins, ViralCervical cancerHuman papilloma virusMolecular markersPrognosisScreening

Identifiers

PMID37000261
PMCPMC11796573
OpenAlexW4362457876

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.