Evidence map›Paper›PMID 37002196›Full record

ArticleNature communications2023

Subcortical serotonin 5HT

M E Flanigan, O J Hon, S D'Ambrosio, K M Boyt, L Hassanein, M Castle, H L Haun, M M Pina, T L Kash

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
6.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 45 citations in OpenAlex.

  1. On the importance of including both sexes in animal studies - insights from home-cage monitoring.Biological reviews of the Cambridge Philosophical Society · 2026
    Review
  2. Selective dysregulation of serotonin dynamics in the anterior cingulate cortex and central amygdala following binge alcohol consumption.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
  3. Selective dysregulation of serotonin dynamics in the anterior cingulate cortex and central amygdala following binge alcohol consumption.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
  4. Article
  5. Review
  6. Review
  7. Review
  8. Review
  9. The Effect of Serotonin 5-HTAddiction biology · 2025
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

M E FlaniganBowles Center for Alcohol Studies, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
O J HonBowles Center for Alcohol Studies, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
S D'AmbrosioBowles Center for Alcohol Studies, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
K M BoytBowles Center for Alcohol Studies, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
L HassaneinBowles Center for Alcohol Studies, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
M CastleBowles Center for Alcohol Studies, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
H L HaunBowles Center for Alcohol Studies, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
M M PinaBowles Center for Alcohol Studies, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
T L KashBowles Center for Alcohol Studies, University of North Carolina School of Medicine, Chapel Hill, NC, USA. Thomas_kash@med.unc.edu.ORCID 0000-0002-4747-4495
University of North Carolina at Chapel Hill · US

Funding

Supplement to Molecular and Cellular Studies on Alcohol's ActionsT32AA007573 · NIAAA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI FULTON T CREWS, Thomas L. Kash · 1997 to 2026
$9.3M
The Role of Serotonin in Alcohol-Withdrawal Induced AnxietyR01AA019454 · NIAAA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Thomas L. Kash · 2010 to 2026
$5.6M
Alcohol-Induced Alterations in Orbitofrontal Cortex Serotonin SignalingR00AA028298 · NIAAA · UNIVERSITY OF MARYLAND BALTIMORE · PI PINA, MELANIE M · 2022 to 2024
$850k
Alcohol-induced alterations in orbitofrontal cortex serotonin signalingK99AA028298 · NIAAA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI PINA, MELANIE M · 2020 to 2021
$253k
Regulation of alcohol-induced social disturbances by lateral habenula serotonin receptorsK99AA030628 · NIAAA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI FLANIGAN, MEGHAN ELIZABETH · 2023 to 2024
$212k
Adaptations in an insular cortex microcircuit following escalated alcohol drinkingF32AA026485 · NIAAA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI PINA, MELANIE M · 2017 to 2020
$142k
Role of nociceptin-containing neurons of the lateral septum in binge-like alcohol consumptionF32AA030494 · NIAAA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI HAUN, HAROLD L · 2022 to 2023
$139k
NIAAA NIH HHS F32 AA026485NIAAA NIH HHS F32 AA030494NIAAA NIH HHS K99 AA028298NIAAA NIH HHS K99 AA030628NIAAA NIH HHS R00 AA028298NIAAA NIH HHS R01 AA019454NIAAA NIH HHS T32 AA007573
6 · The paper itself

Abstract

Binge alcohol consumption induces discrete social and arousal disturbances in human populations that promote increased drinking and accelerate the progression of Alcohol Use Disorder. Here, we show in a mouse model that binge alcohol consumption disrupts social recognition in females and potentiates sensorimotor arousal in males. These negative behavioral outcomes were associated with sex-specific adaptations in serotonergic signaling systems within the lateral habenula (LHb) and the bed nucleus of the stria terminalis (BNST), particularly those related to the receptor 5HT

Indexed as

AlcoholismBinge DrinkingSeptal NucleiAlcohol DrinkingAnimalsArousalEthanolFemaleHumansMaleMiceNeuronsSerotoninEthanolSerotonin

Identifiers

PMID37002196
PMCPMC10066391
OpenAlexW4362467494

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.