Evidence map›Paper›PMID 37007002›Full record

ArticleFrontiers in pharmacology2023

Molecular determinants of μ-conotoxin KIIIA interaction with the human voltage-gated sodium channel Na

Ian H Kimball, Phuong T Nguyen, Baldomero M Olivera, Jon T Sack, Vladimir Yarov-Yarovoy

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. In Silico Conotoxin Studies: Progress and Prospects.Molecules (Basel, Switzerland) · 2024
    Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ian H KimballDepartment of Physiology and Membrane Biology, University of California, Davis, Davis, CA, United States.
Phuong T NguyenDepartment of Physiology and Membrane Biology, University of California, Davis, Davis, CA, United States.
Baldomero M OliveraDepartment of Biology, University of Utah, Salt Lake City, UT, United States.
Jon T SackDepartment of Physiology and Membrane Biology, University of California, Davis, Davis, CA, United States.
Vladimir Yarov-YarovoyDepartment of Physiology and Membrane Biology, University of California, Davis, Davis, CA, United States.

Funding

In silico Safety PharmacologyR01HL128537 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CLANCY, COLLEEN E, SANTANA, LUIS F · 2016 to 2024
$5.7M
Predictive multiscale in silico cardio-pharmacologyU01HL126273 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CLANCY, COLLEEN E · 2015 to 2019
$3.8M
Breakthrough Molecular Dynamics Research via an Anton2 SupercomputerR01GM116961 · NIGMS · CARNEGIE-MELLON UNIVERSITY · PI BLOOD, PHILIP D. · 2016 to 2023
$3.0M
Predoctoral Training in Pharmacological SciencesT32GM099608 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HELL, JOHANNES W · 2012 to 2021
$2.2M
Visualizing endogenous ion channel activationR01NS096317 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI COHEN, BRUCE E, SACK, JON THOMAS · 2016 to 2019
$1.4M
American Heart Association-American Stroke Association 17PRE33670204NHLBI NIH HHS R01 HL128537NHLBI NIH HHS U01 HL126273NIGMS NIH HHS R01 GM116961NIGMS NIH HHS T32 GM099608NINDS NIH HHS R01 NS096317
6 · The paper itself

Abstract

The voltage-gated sodium (Na

Indexed as

conotoxinsNaV1.7 channelprotein-protein interaction (PPI)Rosetta softwarevoltage-gated sodium (NaV) channels

Identifiers

PMID37007002
PMCPMC10060530

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.