ArticleJournal of clinical and experimental dentistry2023
The impact of dental metal restorations on the oral oxidative stress level.
Article in Journal of clinical and experimental dentistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed, 5 citations in OpenAlex.
- Toxicological Assessment of Cobalt-Chromium Dental Alloys: Ion Release, Cytotoxicity, and Possible Systemic Effects.Biological trace element research · 2026Article
- Heavy Metal-Driven Oral Dysbiosis: Salivary Toxicometallomics at the Host-Microbiome Interface Across Pathologies.Life (Basel, Switzerland) · 2026Review
- Evaluation of Oxidative Stress Markers in Post-Surgical Head and Neck Cancer Patients Rehabilitated with Removable Prosthetic Restorations.Antioxidants (Basel, Switzerland) · 2025Article
- Balancing the Oral Redox State: Endogenous and Exogenous Sources of Reactive Oxygen Species and the Antioxidant Role of Lamiaceae and Asteraceae.Dentistry journal · 2025Review
- Salivary Chromium and Cobalt Concentrations in Patients with Dental Metallic Restorations-A Pilot Study.Dentistry journal · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Dental materials may influence the equilibrium between production and destruction of free radicals, thus creating conditions for developing of local or general oxidative stress. Metal ions, emitted from base dental alloys, may cause changes in cell structures and functions. Isoprostane concentration may indicate possible cell damage, caused by free radicals, and can be used for evaluation of the oxidative stress level. The aim of this study was to compare the level of 8-isoPGF2-alpha in saliva in patients with and without metal dental restorations. Material and Methods: 35 patients were divided in two groups according to the presence or absence of metal dental objects. Non-stimulated and stimulated saliva samples were collected. The concentration of 8-isoPGF2-alpha was measured by liquid chromatography tandem mass spectrometry. For statistical analysis non-parametric Mann-Whitney test, Kruskal Wallis test, and Wilcoxon signed-rank test were applied. Results: There was a significant difference in the concentration of 8-isoPGF2-alpha between the samples of non-stimulated and stimulated saliva. The concentration of 8-isoPGF2-alpha in non-stimulated saliva in patients with metal dental restorations was significantly higher than the one in the group of patients without metal objects. Conclusions: The presence of metal dental restorations increases the concentration of 8-isoPGF2-alpha in non-stimulated saliva.
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.