Evidence map›Paper›PMID 37009057›Full record

ArticleCurrent opinion in physiology2023

VASCULAR AND RENAL MECHANISMS OF PREECLAMPSIA.

Xi Wang, Corbin A Shields, Ubong Ekperikpe, Lorena M Amaral, Jan Michael Williams, Denise C Cornelius

Open access · greenAbstract read
In one paragraph

Article in Current opinion in physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. The association between serum magnesium levels and hypertensive disorders of pregnancy.South African family practice : official journal of the South African Academy of Family Practice/Primary Care · 2025
    Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Xi WangDepartment of Pharmacology, University of Mississippi Medical Center.
Corbin A ShieldsDepartment of Emergency Medicine, University of Mississippi Medical Center.
Ubong EkperikpeDepartment of Pharmacology, University of Mississippi Medical Center.
Lorena M AmaralDepartment of Pharmacology, University of Mississippi Medical Center.
Jan Michael WilliamsDepartment of Pharmacology, University of Mississippi Medical Center.
Denise C CorneliusDepartment of Pharmacology, University of Mississippi Medical Center.
University of Mississippi Medical Center · US

Funding

Role of obesity in preeclamptic pregnancy.P20GM121334 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI Ashley C. Johnson, Babbette LaMarca · 2017 to 2026
$26.4M
Hypertension and Cardiorenal Research Training ProgramT32HL105324 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI Joey P. Granger · 2010 to 2026
$7.8M
Hypertension, Inflammation, and Vascular FunctionR01HL151407 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI CORNELIUS, DENISE CRESHUN · 2020 to 2024
$1.9M
Mechanisms involved in the early development of renal disease associated with prepubertal obesityR01DK109133 · NIDDK · UNIVERSITY OF MISSISSIPPI MED CTR · PI WILLIAMS, JAN MICHAEL · 2017 to 2021
$1.7M
The role of IL-33 signaling in the pathophysiology of preeclampsiaF31HL165852 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI WANG, XI · 2022 to 2023
$79k
NHLBI NIH HHS F31 HL165852NHLBI NIH HHS R01 HL151407NHLBI NIH HHS T32 HL105324NIDDK NIH HHS R01 DK109133NIGMS NIH HHS P20 GM121334
6 · The paper itself

Abstract

Preeclampsia (PE) is a multisystem obstetric disorder that affects 2-10% of pregnancies worldwide and it is a leading cause of maternal and fetal morbidity and mortality. The etiology of PE development is not clearly delineated, but since delivery of the fetus and placenta often leads to symptom resolution in the most cases of PE, it is hypothesized that the placenta is the inciting factor of the disease. Current management strategies for PE focus on treating the maternal symptoms to stabilize the mother in an attempt to prolong the pregnancy. However, the efficacy of this management strategy is limited. Therefore, identification of novel therapeutic targets and strategies is needed. Here, we provide a comprehensive overview of the current state of knowledge regarding mechanisms of vascular and renal pathophysiology during PE and discuss potential therapeutic targets directed at improving maternal vascular and renal function.

Indexed as

Preeclampsiarenal dysfunctionvascular dysfunction

Identifiers

PMID37009057
PMCPMC10062189
OpenAlexW4322765704

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.