Evidence map›Paper›PMID 37009872›Full record

ReviewJournal of translational medicine2023

The roles of dietary lipids and lipidomics in gut-brain axis in type 2 diabetes mellitus.

Duygu Ağagündüz, Mehmet Arif Icer, Ozge Yesildemir, Tevfik Koçak, Emine Kocyigit, Raffaele Capasso

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of translational medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
11.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 1 synthesis or guideline pooled it, 64 citations in OpenAlex.

  1. Pooled it
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  8. Special Issue: "Molecular Diagnosis and Treatments of Diabetes Mellitus".International journal of molecular sciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 6 institutions in 3 countries.

Duygu AğagündüzDepartment of Nutrition and Dietetics, Faculty of Health Sciences, Gazi University, 06490, Ankara, Turkey. duyguturkozu@gazi.edu.tr.ORCID 0000-0003-0010-0012
Mehmet Arif IcerDepartment of Nutrition and Dietetics, Faculty of Health Sciences, Amasya University, 05100, Amasya, Turkey.
Ozge YesildemirDepartment of Nutrition and Dietetics, Faculty of Health Sciences, Bursa Uludag University, 16059, Bursa, Turkey.
Tevfik KoçakDepartment of Nutrition and Dietetics, Faculty of Health Sciences, Gazi University, 06490, Ankara, Turkey.
Emine KocyigitDepartment of Nutrition and Dietetics, Faculty of Health Sciences, Ordu University, 52200, Ordu, Turkey.
Raffaele CapassoDepartment of Agricultural Sciences, University of Naples Federico II, Portici, 80055, Naples, Italy. rafcapas@unina.it.
Amasya Üniversitesi · TRBursa Uludağ Üni̇versi̇tesi̇ · TRDepartment of Agricultural Sciences · RUGazi Hastanesi · TRGazi University · TROrdu University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Type 2 diabetes mellitus (T2DM), one of the main types of Noncommunicable diseases (NCDs), is a systemic inflammatory disease characterized by dysfunctional pancreatic β-cells and/or peripheral insulin resistance, resulting in impaired glucose and lipid metabolism. Genetic, metabolic, multiple lifestyle, and sociodemographic factors are known as related to high T2DM risk. Dietary lipids and lipid metabolism are significant metabolic modulators in T2DM and T2DM-related complications. Besides, accumulated evidence suggests that altered gut microbiota which plays an important role in the metabolic health of the host contributes significantly to T2DM involving impaired or improved glucose and lipid metabolism. At this point, dietary lipids may affect host physiology and health via interaction with the gut microbiota. Besides, increasing evidence in the literature suggests that lipidomics as novel parameters detected with holistic analytical techniques have important roles in the pathogenesis and progression of T2DM, through various mechanisms of action including gut-brain axis modulation. A better understanding of the roles of some nutrients and lipidomics in T2DM through gut microbiota interactions will help develop new strategies for the prevention and treatment of T2DM. However, this issue has not yet been entirely discussed in the literature. The present review provides up-to-date knowledge on the roles of dietary lipids and lipidomics in gut-brain axis in T2DM and some nutritional strategies in T2DM considering lipids- lipidomics and gut microbiota interactions are given.

Indexed as

Diabetes Mellitus, Type 2Brain-Gut AxisDietary FatsGlucoseHumansLipidomicsDietary FatsGlucoseDietGut microbiotaLipidomicsLipidsType 2 diabetes mellitus

Identifiers

PMID37009872
PMCPMC10068184
OpenAlexW4362524037

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.