ArticleToxicologic pathology2023
Chronic Inhalation Exposure to Antimony Trioxide Exacerbates the MAPK Signaling in Alveolar Bronchiolar Carcinomas in B6C3F1/N Mice.
Thai-Vu T Ton, Hue-Hua L Hong, Ramesh C Kovi, Keith R Shockley, Shyamal D Peddada, Kevin E Gerrish, Kyathanahalli S Janardhan, Gordon Flake, Mathew D Stout, Robert C Sills and 1 more
Open access · greenAbstract read
In one paragraphArticle in Toxicologic pathology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.5field-weighted citation impact, top 28% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 2 citations in OpenAlex.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
11 authors at 3 institutions in 1 country.
Thai-Vu T TonNational Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA.
Hue-Hua L HongNational Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA.
Ramesh C KoviNational Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA.ORCID 0000-0002-3562-2008 Keith R ShockleyNational Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA.
Shyamal D PeddadaNational Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA.
Kevin E GerrishNational Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA.
Kyathanahalli S JanardhanNational Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA.ORCID 0000-0002-5774-9317 Gordon FlakeNational Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA.
Mathew D StoutNational Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA.
Robert C SillsNational Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA.
Arun R PandiriNational Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA.ORCID 0000-0003-0963-9073 National Institute of Environmental Health Sciences · USMerck & Co., Inc., Rahway, NJ, USA (United States) · USPfizer (United States) · US
Funding
Toxicologic Pathology Evaluations for the National Toxicology ProgramZIAES103319 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI MALARKEY, DAVID · 2016 to 2019
$25.2MPathology Services Supporting the Division Translational ToxicologyZICES103376 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI CESTA, MARK · 2022 to 2025
$23.9MZIA CARCI Carcinogenicity Health Effects innovation Research ProgramZIAES103383 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI PANDIRI, ARUN KUMAR · 2022 to 2025
$13.0MConsumer Products and Therapeutics Research ProgramZIAES103379 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI TAYLOR, KYLA · 2022 to 2025
$9.9MCMPB Central Pathology SupportZ01ES102505 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI SILLS, ROBERT · 2008 to 2008
$5.7MDNA Microarray Data AnalysisZIAES103166 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI SHOCKLEY, KEITH · 2013 to 2025
$1.3MDNTP/NIEHS intramural program ES103319-06 [2021], ES102505-14 [2021], AND ZIA ES103383-01Intramural NIH HHS Z01 ES102505Intramural NIH HHS ZIA ES103319Intramural NIH HHS ZIA ES103383
6 · The paper itselfAbstract
Antimony trioxide (AT) is used as a flame retardant in fabrics and plastics. Occupational exposure in miners and smelters is mainly through inhalation and dermal contact. Chronic inhalation exposure to AT particulates in B6C3F1/N mice and Wistar Han rats resulted in increased incidences and tumor multiplicities of alveolar/bronchiolar carcinomas (ABCs). In this study, we demonstrated
Indexed as
Adenocarcinoma, Bronchiolo-AlveolarLung NeoplasmsAnimalsAntimonyErbB ReceptorsHumansInhalation ExposureMiceMice, Inbred StrainsMitogen-Activated Protein KinasesProto-Oncogene Proteins p21(ras)RatsRats, WistarAntimonyantimony trioxideErbB ReceptorsMitogen-Activated Protein KinasesProto-Oncogene Proteins p21(ras)alveolar/bronchiolar carcinomaantimony trioxideimmunohistochemistryinhalation exposureMAPK pathwaymouse
Identifiers
PMID37009983
PMCPMC11368139
OpenAlexW4362507464
What Socratic holds
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