Evidence map›Paper›PMID 37010087›Full record

ReviewJournal of proteome research2023

Deciphering the Properties and Functions of Glycoproteins Using Quantitative Proteomics.

Senhan Xu, Xing Xu, Ronghu Wu

Open access · hybridAbstract readReview
In one paragraph

Review in Journal of proteome research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Integrating the analysis of human biopsies using post-translational modifications proteomics.Protein science : a publication of the Protein Society · 2024
    Review
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Senhan Xu
Xing Xu
Georgia Institute of Technology · US

Funding

Effective MS-Based Methods for Unraveling Cell Surface Protein InteractionsR01GM118803 · NIGMS · GEORGIA INSTITUTE OF TECHNOLOGY · PI WU, RONGHU · 2017 to 2024
$2.4M
Supplemental Funds for a Thermo Scientific Q Exactive HF Mass SpectrometerR01GM127711 · NIGMS · GEORGIA INSTITUTE OF TECHNOLOGY · PI WU, RONGHU · 2020 to 2023
$1.4M
NIGMS NIH HHS R01 GM118803NIGMS NIH HHS R01 GM127711
6 · The paper itself

Abstract

Glycosylation is one of the most common and important protein modifications, and it regulates the properties and functions of a wide range of proteins. Aberrant glycosylation is directly related to human diseases. Recently, with the advancement of mass spectrometry (MS) instrumentation and MS-based glycoproteomic methods, global characterization of glycoproteins in complex biological samples has become possible. Using quantitative proteomics, the abundance of glycoproteins in different samples can be quantified, which provides a wealth of information to further our understanding of protein functions, cellular activities, and the molecular mechanisms of diseases. In this review, we discuss quantitative proteomic methods used for comprehensive analysis of protein glycosylation, and cover the applications of quantitative glycoproteomics to unveil the properties and functions of glycoproteins and their association with various diseases. It is expected that quantitative proteomic methods will be extensively applied to explore the role of protein glycosylation in complex biological systems, and to identify glycoproteins as biomarkers for disease detection and as therapeutic targets for disease treatment.

Indexed as

GlycoproteinsProteomicsGlycosylationHumansMass SpectrometryProtein Processing, Post-TranslationalGlycoproteinsglycoproteomicsidentification and quantification of glycoproteinsmass spectrometryprotein glycosylationquantitative proteomicsSILACTMT

Identifiers

PMID37010087
PMCPMC10243117
OpenAlexW4362506698

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.