ReviewThe lancet. Diabetes & endocrinology2023
Clinical consensus guideline on the management of phaeochromocytoma and paraganglioma in patients harbouring germline SDHD pathogenic variants.
Open access · greenAbstract readReview
In one paragraph
Review in The lancet. Diabetes & endocrinology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 2 pooled it
24.8field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed, 2 syntheses or guidelines pooled it, 78 citations in OpenAlex.
- Clinical characteristics and prognosis ofJournal of medical genetics · 2026Pooled it
- Japan Endocrine Society Clinical Practice Guideline for the Diagnosis and Management of Pheochromocytoma and Paraganglioma 2025.Endocrine journal · 2026Guideline
- MBD1-Mediated SDHD Methylation Aggravates Preeclampsia Progression via Triggering Mitochondrial Dysfunction.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- Comparison ofMolecular imaging and biology · 2026Article
- Molecular imaging and radioligand therapies in pheochromocytomas and paragangliomas.Endocrine-related cancer · 2026Review
- FROM DISCOVERY SCIENCE TO THE CLINIC - HERITABLE ENDOCRINE CANCERS AND RELATED DISORDERS: Functional imaging in hereditary endocrine neoplasms: evolving modalities and clinical implications.Endocrine-related cancer · 2026Review
- [European journal of nuclear medicine and molecular imaging · 2026Article
- Pheochromocytomas and Paragangliomas.Endocrinology and metabolism clinics of North America · 2026Review
- Management of para-aortic paraganglioma in a patient with uncontrolled blood pressure-a case report.Journal of surgical case reports · 2026Article
- Two Cases of Hereditary Paraganglioma-Pheochromocytoma Syndrome in Siblings, Caused by a Novel Succinate Dehydrogenase Complex Subunit D Variant.IJU case reports · 2026Article
- A rare case of giant paraganglioma in the first porta hepatis area associated with neurofibromatosis type 1.Hepatobiliary surgery and nutrition · 2026Article
- Intracardiac paraganglioma in the left atrium in the context of a hereditary syndrome due to SDHD mutation: a case report.European heart journal. Case reports · 2026Article
- Surgical resection versus stereotactic radiosurgery for succinate dehydrogenase-related hereditary head and neck paragangliomas.Journal of neuro-oncology · 2026Article
- The evolving roles of pathologists in paragangliomas and pheochromocytomas.Virchows Archiv : an international journal of pathology · 2026Review
- A contemporary overview of multiple endocrine neoplasia syndromes: MEN syndromes 1-5 and beyond.Endocrine oncology (Bristol, England) · 2026Review
- Quantitative proteomic analysis of pathological and physiological ovarian aging: model evaluation, molecular mechanisms, and identification of early biomarkers and therapeutic targets.Journal of ovarian research · 2025Article
- Management of Head and Neck Paragangliomas: AGREE II Appraisal of Clinical Practice Guidelines.Annals of surgical oncology · 2025Article
- [European journal of nuclear medicine and molecular imaging · 2025Article
- Approach to the Patient With Metastatic Pheochromocytoma and Paraganglioma.The Journal of clinical endocrinology and metabolism · 2025Article
- Genetic Testing Referral Rates for Pheochromocytoma and Paraganglioma in an Academic Tertiary Centre.Clinical endocrinology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
43 authors at 20 institutions in 12 countries.
David TaïebDepartment of Nuclear Medicine, Aix-Marseille University, La Timone University Hospital, Marseille, France.
George B WannaDepartment of Otolaryngology-Head and Neck Surgery, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Maleeha AhmadDepartment of Neurosurgery, Stanford University School of Medicine, Palo Alto, CA, USA.
Charlotte Lussey-LepoutreUniversité Paris Cité, Inserm, PARCC, Equipe Labellisée par la Ligue contre le Cancer, Paris, France; Department of Nuclear Medicine, Pitié-Salpêtrière Hospital, Sorbonne University, Paris, France.
Nancy D PerrierDepartment of Surgical Oncology, MD Anderson Cancer Center, Houston, TX, USA.
Svenja NöltingSvenja Nölting, Department of Endocrinology, Diabetology, and Clinical Nutrition, University Hospital Zurich and University of Zurich, Zurich, Switzerland.
Laurence AmarUniversité Paris Cité, Inserm, PARCC, Equipe Labellisée par la Ligue contre le Cancer, Paris, France; Unité d'hypertension artérielle, Hôpital Européen Georges Pompidou, Assistance Publique-Hôpitaux de Paris, Paris, France.
Henri J L M TimmersDepartment of Internal Medicine, Radboud University Medical Center, Nijmegen, Netherlands.
Zachary G SchwamDepartment of Otolaryngology-Head and Neck Surgery, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Anthony L EstreraDepartment of Cardiothoracic and Vascular Surgery, UTHealth Houston, McGovern Medical School, Memorial Hermann Hospital Heart and Vascular Institute, Houston, TX, USA.
Michael LimDepartment of Neurosurgery, Stanford University School of Medicine, Palo Alto, CA, USA.
Erqi Liu PollomDepartment of Radiation Oncology, Stanford University School of Medicine, Palo Alto, CA, USA.
Lucas VitzthumDepartment of Radiation Oncology, Stanford University School of Medicine, Palo Alto, CA, USA.
Isabelle BourdeauDivision of Endocrinology, Department of Medicine and Research Center, Centre Hospitalier de l'Université de Montréal, Montréal, QC, Canada.
Ruth T CaseyDepartment of Medical Genetics, NIHR Cambridge Biomedical Research Centre, Cancer Research UK Cambridge Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, UK.
Frédéric CastinettiDepartment of Endocrinology, Aix-Marseille University, Conception University Hospital, Marseille, France; INSERM U1251, Aix-Marseille University, Conception University Hospital, Marseille, France.
Roderick Clifton-BlighDepartment of Endocrinology, Royal North Shore Hospital, Sydney, NSW, Australia; Cancer Genetics Laboratory, Kolling Institute, University of Sydney, Sydney, NSW, Australia.
Eleonora P M CorssmitDepartment of Endocrinology, Center of Endocrine Tumors Leiden, Leiden University Medical Centre, Leiden, Netherlands.
Ronald R de KrijgerDepartment of Pathology, University Medical Center Utrecht, Utrecht, Netherlands; Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands.
Jaydira Del RiveroDevelopmental Therapeutics Branch, Rare Tumor Initiative, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Graeme EisenhoferInstitute of Clinical Chemistry and Laboratory Medicine, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Hans K GhayeeDivision of Endocrinology and Metabolism, Department of Medicine, Malcom Randall VA Medical Center, University of Florida, Gainesville, FL, USA.
Anne-Paule Gimenez-RoqueploUniversité Paris Cité, Inserm, PARCC, Equipe Labellisée par la Ligue contre le Cancer, Paris, France; Département de Médecine Génomique des Tumeurs et des Cancers, Hôpital Européen Georges Pompidou, Assistance Publique-Hôpitaux de Paris, Paris, France.
Ashley GrossmanGreen Templeton College, University of Oxford, Oxford, UK; NET Unit, Royal Free Hospital, London, UK.
Alessio ImperialeDepartment of Nuclear Medicine and Molecular Imaging, Institut de Cancérologie de Strasbourg Europe, IPHC, UMR 7178, CNRS, University of Strasbourg, Strasbourg, France.
Jeroen C JansenDepartment of Otorhinolaryngology, Leiden University Medical Centre, Leiden, Netherlands.
Abhishek JhaSection on Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.
Michiel N KerstensDepartment of Endocrinology, University Medical Center Groningen, Groningen, Netherlands.
Henricus P M KunstDepartment of Otolaryngology and Head & Neck Surgery, Dutch Academic Alliance Skull Base Pathology, Radboud University Medical Center, Nijmegen, Netherlands; Department of Otolaryngology and Head & Neck Surgery, Dutch Academic Alliance Skull Base Pathology, Maastricht University Medical Center, Maastricht, Netherlands.
James K LiuDepartment of Neurosurgical Surgery, Rutgers New Jersey Medical School, Newark, NJ, USA.
Eamonn R MaherDepartment of Medical Genetics, NIHR Cambridge Biomedical Research Centre, Cancer Research UK Cambridge Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, UK.
Daniele MarchioniDepartment of Otorhinolaryngology and Head and Neck Surgery, University Hospital of Verona, Verona, Italy.
Leilani B Mercado-AsisSection of Endocrinology and Metabolism, Department of Medicine, Faculty of Medicine & Surgery, University of Santo Tomas Hospital, University of Santo Tomas, Manila, Philippines.
Ozgur MeteDepartment of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada; Endocrine Pathology Society, Toronto, ON, Canada.
Mitsuhide NaruseMedical Center and Endocrine Center, Ijinkai Takeda General Hospital, Kyoto, Japan.
Naris NilubolSurgical Oncology Program, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Neeta Pandit-TaskarDepartment of Radiology, Molecular Imaging and Therapy Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Frédéric SebagDepartment of Endocrine Surgery, Aix-Marseille University, Conception University Hospital, Marseille, France.
Akiyo TanabeDivision of Diabetes, Endocrinology, and Metabolism, National Center for Global Health and Medicine, Tokyo, Japan.
Jiri WidimskyThird Department of Medicine, Department of Endocrinology and Metabolism of the First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic.
Leah MeuterDepartment of Physician Assistant Studies, Stanford University School of Medicine, Palo Alto, CA, USA.
Jacques W M LendersDepartment of Medicine ΙΙI, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany; Department of Internal Medicine, Radboud University Medical Center, Nijmegen, Netherlands.
Karel PacakSection on Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA. Electronic address: karel@mail.nih.gov.
Stanford University · USInserm · FRNational Institutes of Health · USRadboud University Nijmegen · NLAix-Marseille Université · FRIcahn School of Medicine at Mount Sinai · USLeiden University Medical Center · NLUniversity of Cambridge · GBCentre Hospitalier de l’Université de Montréal · CACentre National de la Recherche Scientifique · FRCharles University · CZIjinkai Takeda General Hospital · JPMemorial Hermann · USMemorial Sloan Kettering Cancer Center · USNational Center for Global Health and Medicine · JPRutgers, The State University of New Jersey · USThe Royal Free Hospital · GBThe University of Sydney · AUThe University of Texas MD Anderson Cancer Center · USUniversity Hospital Carl Gustav Carus · DE
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4MDiagnosis, Pathophysiology And Molecular Biology of Pheochromocytoma and ParagangliomaZIAHD008735 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI PACAK, KAREL · 2009 to 2024
$28.4MTherapeutic targets and novel anticancer agents for endocrine cancersZIABC011286 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI NILUBOL, NARIS · 2010 to 2025
$16.6MIntramural NIH HHS ZIA HD008735NCI NIH HHS P30 CA008748
Abstract
Patients with germline SDHD pathogenic variants (encoding succinate dehydrogenase subunit D; ie, paraganglioma 1 syndrome) are predominantly affected by head and neck paragangliomas, which, in almost 20% of patients, might coexist with paragangliomas arising from other locations (eg, adrenal medulla, para-aortic, cardiac or thoracic, and pelvic). Given the higher risk of tumour multifocality and bilaterality for phaeochromocytomas and paragangliomas (PPGLs) because of SDHD pathogenic variants than for their sporadic and other genotypic counterparts, the management of patients with SDHD PPGLs is clinically complex in terms of imaging, treatment, and management options. Furthermore, locally aggressive disease can be discovered at a young age or late in the disease course, which presents challenges in balancing surgical intervention with various medical and radiotherapeutic approaches. The axiom-first, do no harm-should always be considered and an initial period of observation (ie, watchful waiting) is often appropriate to characterise tumour behaviour in patients with these pathogenic variants. These patients should be referred to specialised high-volume medical centres. This consensus guideline aims to help physicians with the clinical decision-making process when caring for patients with SDHD PPGLs.
Indexed as
Adrenal Gland NeoplasmsParagangliomaPheochromocytomaGerm-Line MutationHumansPractice Guidelines as TopicSuccinate DehydrogenaseSDHD protein, humanSuccinate Dehydrogenase
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.