ArticleThe Journal of clinical endocrinology and metabolism2023
Sex-specific Association Between Adipose Tissue Inflammation and Vascular and Metabolic Complications of Obesity.
Article in The Journal of clinical endocrinology and metabolism, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 27 citations in OpenAlex.
- Challenges and knowledge gaps in sex differences in cardio-kidney-metabolic syndrome across the lifespan.Biology of sex differences · 2026Review
- Estradiol treatment induces both shared and unique gene regulation and networks in adipose cell types of gonadectomized obese XX and XY mice.Biology of sex differences · 2026Article
- Endotoxins and Metabolic Endotoxemia in Obesity and Associated Noncommunicable Diseases: A Focus on Sex Differences.Biomolecules · 2026Review
- Waist circumference partially mediates the non-linear association between TyHGB and MASLD in non-diabetic Japanese adults.Frontiers in nutrition · 2026Article
- Relationship between serum lipids/adipokines and obesity/hypertension in very-preterm infants during early childhood and preadolescence.Pediatric research · 2025Article
- The association of ultra-processed foods and risk of sarcopenia among community-dwelling older adults.BMC geriatrics · 2025Article
- The long-term effect of metabolic bariatric surgery on innate immune cell phenotype and function.International journal of obesity (2005) · 2025Observational
- Underpinnings of heart failure with preserved ejection fraction in women - From prevention to improving function. A co-publication with the American Journal of Preventive Cardiology and the Journal of Cardiac Failure.American journal of preventive cardiology · 2025Article
- Trained Immunity Induced by Oxidized Low-Density Lipoprotein Is Dependent on Glutaminolysis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
- Associations of leptin levels with psychopathology, BDNF and inflammatory cytokines in patients with chronic schizophrenia as well as gender differences.BMC psychiatry · 2025Article
- Adipocytokine Protein Expression from Visceral Fat Differs Significantly Based on Diet, Sex, and Age in C3H/HeJ Mice Fed Long-Term, High-Fat Diets, ± Ammonium-Hydroxide-Supplemented Dietary Protein.Current issues in molecular biology · 2025Article
- Article
- Association between systemic immune inflammation index and adolescent obesity in a cross-sectional analysis.Scientific reports · 2025Article
- Circulating FGF21 is lower in South Asians compared with Europids with type 2 diabetes mellitus.Endocrine connections · 2025Article
- High Body Roundness Index Is Associated With Unhealthy Sleep Patterns: Insights From NHANES (2007-2014).Brain and behavior · 2025Article
- Sex-specific association of visceral and subcutaneous adipose tissue volumes with systemic inflammation and innate immune cells in people living with obesity.International journal of obesity (2005) · 2024Observational
- Association Between Clonal Hematopoiesis Driver Mutations, Immune Cell Function, and the Vasculometabolic Complications of Obesity.Journal of the American Heart Association · 2024Article
- Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 4 countries.
Funding
Abstract
contextAdipose tissue (AT) inflammation predisposes to insulin resistance and metabolic syndrome in obesity.
objectiveTo investigate the association between adipocyte size, AT inflammation, systemic inflammation, and metabolic and atherosclerotic complications of obesity in a sex-specific manner.
designCross-sectional cohort study.
settingUniversity hospital in the Netherlands.
participantsA total of 302 adult subjects with a body mass index (BMI) ≥ 27 kg/m2.
main outcome measuresWe obtained subcutaneous abdominal fat biopsies and systematically assessed, in a sex-specific manner, associations of several parameters of AT inflammation (including adipocyte size, macrophage content, crown-like structures, and gene expression) to biomarkers of systemic inflammation, leukocyte number and function, and to the presence of metabolic syndrome, insulin resistance, and carotid atherosclerotic plaques, assessed with ultrasound.
resultsAdipocyte size was associated with metabolic syndrome and AT macrophage content with insulin resistance. In contrast, none of the AT parameters was associated with carotid atherosclerosis, although mRNA expression of the anti-inflammatory IL-37 was associated with a lower intima-media thickness. We revealed profound sex-specific differences, with an association between BMI and adipocyte size, and between adipocyte size and metabolic syndrome in men only. Also, only men showed an association between adipocyte size, AT expression of leptin and MCP-1, and AT macrophage numbers, and between AT inflammation (crown-like structure number) and several circulating inflammatory proteins, including high specificity C-reactive protein, and IL-6.
conclusionsInflammation in abdominal subcutaneous adipose tissue is more related to the metabolic than the atherosclerotic complications of obesity, and there are profound sex-specific differences in the association between BMI, adipocyte size, AT inflammation, and systemic inflammation, which are much stronger in men than women.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.