Evidence map›Paper›PMID 37017672›Full record

ArticleCritical reviews in eukaryotic gene expression2023

Spatiotemporal Epigenetic Control of the Histone Gene Chromatin Landscape during the Cell Cycle.

Andrew J Fritz, Prachi N Ghule, Rabail Toor, Louis Dillac, Jonah Perelman, Joseph Boyd, Jane B Lian, Johnathan A R Gordon, Seth Frietze, Andre Van Wijnen and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Critical reviews in eukaryotic gene expression, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Differential responses to maternal diabetes in embryo and visceral yolk sac.Frontiers in cell and developmental biology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Andrew J FritzDepartment of Biochemistry, University of Vermont, Burlington, Vermont, USA; University of Vermont Cancer Center, Burlington, Vermont, USA.
Prachi N GhuleDepartment of Biochemistry, University of Vermont, Burlington, Vermont, USA; University of Vermont Cancer Center, Burlington, Vermont, USA.
Rabail ToorDepartment of Biochemistry, University of Vermont, Burlington, Vermont, USA; University of Vermont Cancer Center, Burlington, Vermont, USA.
Louis DillacDepartment of Biochemistry, University of Vermont, Burlington, Vermont, USA; University of Vermont Cancer Center, Burlington, Vermont, USA.
Jonah PerelmanDepartment of Biochemistry, University of Vermont, Burlington, Vermont, USA.
Joseph BoydCollege of Nursing and Health Sciences, University of Vermont, Burlington, Vermont, USA.
Jane B LianDepartment of Biochemistry, University of Vermont, 89 Beaumont Ave., Given E210B, Burlington, VT 05405, USA; University of Vermont Cancer Center, Burlington, Vermont, USA.
Johnathan A R GordonDepartment of Biochemistry, University of Vermont, Burlington, Vermont, USA; University of Vermont Cancer Center, Burlington, Vermont, USA.
Seth FrietzeUniversity of Vermont Cancer Center, Burlington, Vermont, USA; College of Nursing and Health Sciences, University of Vermont, Burlington, Vermont, USA.
Andre Van WijnenDepartment of Biochemistry, University of Vermont, Burlington, Vermont, USA.
Janet L SteinDepartment of Biochemistry, University of Vermont, 89 Beaumont Ave., Given E210E, Burlington, VT 05405, USA; University of Vermont Cancer Center, Burlington, Vermont, USA.
Gary S SteinDepartment of Biochemistry, University of Vermont, 89 Beaumont Ave., Given E210E, Burlington, VT 05405, USA; University of Vermont Cancer Center, Burlington, Vermont, USA.
University of Vermont · US

Funding

Understanding Factors Influencing COVID-19 Testing and Vaccination in Immigrant Low-income and Homeless Populations and Testing Targeted InterventionsU54GM115516 · NIGMS · MAINEHEALTH · PI CLIFFORD JAMES ROSEN, Gary S. Stein · 2017 to 2026
$51.6M
Project 3: MANCR Mediates Epigenetic Mechanisms for Survival of Advanced Breast CancerP01CA240685 · NCI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI STEIN, GARY S. · 2021 to 2025
$8.7M
Chromatin Organization Regulates OsteogenesisR01DE029311 · NIDCR · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI LIAN, JANE B., STEIN, GARY S. · 2020 to 2024
$2.5M
Deciphering the molecular mechanisms of histone code recognition by ATAD2/BR01GM129338 · NIGMS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI FRIETZE, SETH E, GLASS, KAREN CHAMPAGNE · 2018 to 2022
$2.1M
Understanding Ikaros molecular functions for targeted therapies of pre-B ALLR01CA230618 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FRIETZE, SETH E, SCHJERVEN, HILDE · 2018 to 2022
$1.8M
Supplement to AWD32581 - Fritz fellowship F32CA220935F32CA220935 · NCI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI FRITZ, ANDREW J · 2018 to 2021
$216k
NCI NIH HHS F32 CA220935NCI NIH HHS P01 CA240685NCI NIH HHS R01 CA230618NIDCR NIH HHS R01 DE029311NIGMS NIH HHS R01 GM129338NIGMS NIH HHS U54 GM115516
6 · The paper itself

Abstract

Higher-order genomic organization supports the activation of histone genes in response to cell cycle regulatory cues that epigenetically mediates stringent control of transcription at the G1/S-phase transition. Histone locus bodies (HLBs) are dynamic, non-membranous, phase-separated nuclear domains where the regulatory machinery for histone gene expression is organized and assembled to support spatiotemporal epigenetic control of histone genes. HLBs provide molecular hubs that support synthesis and processing of DNA replication-dependent histone mRNAs. These regulatory microenvironments support long-range genomic interactions among non-contiguous histone genes within a single topologically associating domain (TAD). HLBs respond to activation of the cyclin E/CDK2/NPAT/HINFP pathway at the G1/S transition. HINFP and its coactivator NPAT form a complex within HLBs that controls histone mRNA transcription to support histone protein synthesis and packaging of newly replicated DNA. Loss of HINFP compromises H4 gene expression and chromatin formation, which may result in DNA damage and impede cell cycle progression. HLBs provide a paradigm for higher-order genomic organization of a subnuclear domain that executes an obligatory cell cycle-controlled function in response to cyclin E/CDK2 signaling. Understanding the coordinately and spatiotemporally organized regulatory programs in focally defined nuclear domains provides insight into molecular infrastructure for responsiveness to cell signaling pathways that mediate biological control of growth, differentiation phenotype, and are compromised in cancer.

Indexed as

ChromatinHistonesCell CycleCell Cycle ProteinsCyclin EEpigenesis, GeneticNuclear ProteinsCell Cycle ProteinsChromatinCyclin EHistonesNuclear Proteins

Identifiers

PMID37017672
PMCPMC10826887
OpenAlexW4312588581

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.