Evidence map›Paper›PMID 37017807›Full record

ArticleMolecular genetics and genomics : MGG2023

Whole-genome sequencing and comparative genomic analysis of potential biotechnological strains of Trichoderma harzianum, Trichoderma atroviride, and Trichoderma reesei.

Rafaela Rossi Rosolen, Maria Augusta Crivelente Horta, Paulo Henrique Campiteli de Azevedo, Carla Cristina da Silva, Danilo Augusto Sforca, Gustavo Henrique Goldman, Anete Pereira de Souza

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular genetics and genomics : MGG, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Review
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  6. Article
  7. EngineeringAIMS microbiology · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Rafaela Rossi RosolenCenter for Molecular Biology and Genetic Engineering (CBMEG), University of Campinas (UNICAMP), Cidade Universitária Zeferino Vaz, Campinas, SP, Brazil.ORCID http://orcid.org/0000-0002-8964-4034
Maria Augusta Crivelente HortaCenter for Molecular Biology and Genetic Engineering (CBMEG), University of Campinas (UNICAMP), Cidade Universitária Zeferino Vaz, Campinas, SP, Brazil.ORCID http://orcid.org/0000-0003-2159-5296
Paulo Henrique Campiteli de AzevedoCenter for Molecular Biology and Genetic Engineering (CBMEG), University of Campinas (UNICAMP), Cidade Universitária Zeferino Vaz, Campinas, SP, Brazil.ORCID http://orcid.org/0000-0001-9564-9336
Carla Cristina da SilvaCenter for Molecular Biology and Genetic Engineering (CBMEG), University of Campinas (UNICAMP), Cidade Universitária Zeferino Vaz, Campinas, SP, Brazil.
Danilo Augusto SforcaCenter for Molecular Biology and Genetic Engineering (CBMEG), University of Campinas (UNICAMP), Cidade Universitária Zeferino Vaz, Campinas, SP, Brazil.ORCID http://orcid.org/0000-0003-2304-8712
Gustavo Henrique GoldmanFaculty of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo (USP), Ribeirão Preto, SP, Brazil.ORCID http://orcid.org/0000-0002-2986-350X
Anete Pereira de SouzaCenter for Molecular Biology and Genetic Engineering (CBMEG), University of Campinas (UNICAMP), Cidade Universitária Zeferino Vaz, Campinas, SP, Brazil. anete@unicamp.br.ORCID http://orcid.org/0000-0003-3831-9829
Universidade Estadual de Campinas (UNICAMP) · BRUniversidade de Ribeirão Preto · BR

Funding

Brazilian National Council for Technological and Scientific Development 312777/2018-3Coordination for the Improvement of Higher Education Personnel 88882.160095/2013-01Coordination for the Improvement of Higher Education Personnel 88887.482201/2020-00Coordination for the Improvement of Higher Education Personnel 88887.612254/2021-00Fundação de Amparo à Pesquisa do Estado de São Paulo 2015/09202-0Fundação de Amparo à Pesquisa do Estado de São Paulo 2018/19660-4Fundação de Amparo à Pesquisa do Estado de São Paulo 2020/10536-9Fundação de Amparo à Pesquisa do Estado de São Paulo 2020/13420-1
6 · The paper itself

Abstract

Trichoderma atroviride and Trichoderma harzianum are widely used as commercial biocontrol agents against plant diseases. Recently, T. harzianum IOC-3844 (Th3844) and T. harzianum CBMAI-0179 (Th0179) demonstrated great potential in the enzymatic conversion of lignocellulose into fermentable sugars. Herein, we performed whole-genome sequencing and assembly of the Th3844 and Th0179 strains. To assess the genetic diversity within the genus Trichoderma, the results of both strains were compared with strains of T. atroviride CBMAI-00020 (Ta0020) and T. reesei CBMAI-0711 (Tr0711). The sequencing coverage value of all genomes evaluated in this study was higher than that of previously reported genomes for the same species of Trichoderma. The resulting assembly revealed total lengths of 40 Mb (Th3844), 39 Mb (Th0179), 36 Mb (Ta0020), and 32 Mb (Tr0711). A genome-wide phylogenetic analysis provided details on the relationships of the newly sequenced species with other Trichoderma species. Structural variants revealed genomic rearrangements among Th3844, Th0179, Ta0020, and Tr0711 relative to the T. reesei QM6a reference genome and showed the functional effects of such variants. In conclusion, the findings presented herein allow the visualization of genetic diversity in the evaluated strains and offer opportunities to explore such fungal genomes in future biotechnological and industrial applications.

Indexed as

TrichodermaGenomicsHypocrealesPhylogenyComparative analysisGenomesOrthology analysisStructural variant analysisTrichoderma

Identifiers

PMID37017807
OpenAlexW4362601801

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.