Evidence map›Paper›PMID 37019861›Full record

ArticleJournal of neurogastroenterology and motility2023

Prevalence of Non-erosive Esophageal Phenotypes in Children: A European Multicenter Study.

Elisa Blasi, Ettore Stefanelli, Renato Tambucci, Silvia Salvatore, Paola De Angelis, Paolo Quitadamo, Claudia Pacchiarotti, Giovanni Di Nardo, Fanj Crocco, Enrico Felici and 6 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurogastroenterology and motility, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it, 7 citations in OpenAlex.

  1. Guideline
  2. Guideline
  3. Review
  4. Review
  5. Article
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  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 9 institutions in 2 countries.

Elisa BlasiNeurogastroenterology and Motility Unit, Department of Gastroenterology, Great Ormond Street Hospital for Children, London, UK.
Ettore StefanelliDepartment of Medical and Surgical Sciences, Pediatric Unit, University Magna Graecia of Catanzaro, Catanzaro, Italy.
Renato TambucciDigestive Endoscopy and Surgery Unit, Bambino Gesù Children's Hospital - Research Institute IRCCS, Rome, Italy.
Silvia SalvatorePediatric Department, University of Insubria, Hospital "F. Del Ponte", Varese, Italy.
Paola De AngelisDigestive Endoscopy and Surgery Unit, Bambino Gesù Children's Hospital - Research Institute IRCCS, Rome, Italy.
Paolo QuitadamoDepartment of Pediatrics, A.O.R.N. Santobono-Pausilipon, Napoli, Italy.
Claudia PacchiarottiNESMOS Department, Faculty of Medicine and Psychology, Sapienza University of Rome, Pediatric Unit, Sant'Andrea University Hospital, Rome, Italy.
Giovanni Di NardoNESMOS Department, Faculty of Medicine and Psychology, Sapienza University of Rome, Pediatric Unit, Sant'Andrea University Hospital, Rome, Italy.
Fanj CroccoPediatric and Pediatric Emergency Unit, Children Hospital, AO SS Antonio e Biagio e C. Arrigo, Alessandria, Italy.
Enrico FeliciPediatric and Pediatric Emergency Unit, Children Hospital, AO SS Antonio e Biagio e C. Arrigo, Alessandria, Italy.
Valentina GiorgioDepartment of Woman and Child Health and Public Health, Public Health Area, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Nicoletta StaropoliA.O.U. Mater Domini, University Magna Graecia of Catanzaro, Catanzaro, Italy.
Simona SestitoDepartment of Medical and Surgical Sciences, Pediatric Unit, University Magna Graecia of Catanzaro, Catanzaro, Italy.
Efstratios SaliakellisNeurogastroenterology and Motility Unit, Department of Gastroenterology, Great Ormond Street Hospital for Children, London, UK.
Osvaldo BorrelliNeurogastroenterology and Motility Unit, Department of Gastroenterology, Great Ormond Street Hospital for Children, London, UK.
Licia PensabeneNeurogastroenterology and Motility Unit, Department of Gastroenterology, Great Ormond Street Hospital for Children, London, UK.
Magna Graecia University · ITUniversity College London · GBAzienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo · ITIstituti di Ricovero e Cura a Carattere Scientifico · ITSapienza University of Rome · ITAgostino Gemelli University Polyclinic · ITGreat Ormond Street Hospital · GBOspedale Filippo Del Ponte Varese · ITSantobono Children's Hospital · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background/Aims: Since available data on pediatric non-erosive esophageal phenotypes (NEEPs) are scant, we investigated their prevalence and the phenotype-dependent treatment response in these children. Methods: Over a 5-year period, children with negative upper endoscopy, who underwent esophageal pH-impedance (off-therapy) for persisting symptoms not responsive to proton pump inhibitor (PPI)-treatment, were recruited. Based on the results of acid reflux index (RI) and symptom association probability (SAP), patients were categorized into: (1) abnormal RI (non-erosive reflux disease [NERD]), (2) normal RI and abnormal SAP (reflux hypersensitivity [RH]), (3) normal RI and normal SAP (functional heartburn [FH]), and (4) normal RI and not-reliable SAP (normal-RI-not otherwise-specified [normal-RI-NOS]). For each subgroup, treatment response was evaluated. Results: Out of 2333 children who underwent esophageal pH-impedance, 68 cases, including 18 NERD, 14 RH, 26 FH, and 10 normal-RI-NOS were identified as fulfilling the inclusion criteria and were analyzed. Considering symptoms before endoscopy, chest pain was more reported in NERD than in other cases (6/18 vs 5/50, Conclusions: FH may be the most common pediatric NEEP. At long-term follow-up, there was a trend toward a more frequent complete symptom resolution with PPI-therapy in NERD patients while other groups did not benefit from extended acid-suppressive-treatment.

Indexed as

ChildrenFunctional heartburnGastroesophageal reflux diseaseNon-erosive reflux diseaseReflux hypersensitivity

Identifiers

PMID37019861
PMCPMC10083122
OpenAlexW4362637329

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.