Evidence map›Paper›PMID 37020302›Full record

ArticleMolecular brain2023

FMRP binds Per1 mRNA and downregulates its protein expression in mice.

Xiangrong Tang, Jing Zhang, Xin Li, Ying Hu, Dengfeng Liu, Jia-Da Li, Renbin Lu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular brain, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Xiangrong TangHunan Key Laboratory of Molecular Precision Medicine, Xiangya Hospital, Central South University, Changsha, China.
Jing ZhangCenter for Medical Genetics, School of Life Sciences, Central South University, Changsha, 410078, Hunan, China.
Xin LiCenter for Medical Genetics, School of Life Sciences, Central South University, Changsha, 410078, Hunan, China.
Ying HuCenter for Medical Genetics, School of Life Sciences, Central South University, Changsha, 410078, Hunan, China.
Dengfeng LiuCenter for Medical Genetics, School of Life Sciences, Central South University, Changsha, 410078, Hunan, China.
Jia-Da LiCenter for Medical Genetics, School of Life Sciences, Central South University, Changsha, 410078, Hunan, China. lijiada@sklmg.edu.cn.
Renbin LuHunan Key Laboratory of Molecular Precision Medicine, Xiangya Hospital, Central South University, Changsha, China. lurenbin@sklmg.edu.cn.
Central South University · CN

Funding

China Postdoctoral Science Foundation 2021T140746National Natural Science Foundation of China 31972913National Natural Science Foundation of China 82101960
6 · The paper itself

Abstract

FMRP, an RNA-binding protein, has previously shown to be involved in regulation of circadian rhythms in flies and mice. However, the molecular mechanism remains elusive. Here we demonstrate that core circadian component Per1 mRNA was a target of FMRP and the association leads to reduced PER1 expression. In Fmr1 KO mice, the oscillation of PER1 protein expression was significantly affected in a temporal and tissue-dependent pattern when compared to WT mice. Our work thus identified Per1 mRNA as a novel target of FMRP and suggested a potential role of FMRP in regulation of circadian function.

Indexed as

Circadian RhythmTranscription FactorsAnimalsFragile X Messenger Ribonucleoprotein 1MicePeriod Circadian ProteinsRNA, MessengerFmr1 protein, mouseFragile X Messenger Ribonucleoprotein 1Per1 protein, mousePeriod Circadian ProteinsRNA, MessengerTranscription FactorsCircadian rhythmFMRPFXSPer1

Identifiers

PMID37020302
PMCPMC10077598
OpenAlexW4362608108

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.