Evidence map›Paper›PMID 37028941›Full record

ArticleNeurology(R) neuroimmunology & neuroinflammation2023

Comparative Effects of Domain-Specific Human Monoclonal Antibodies Against LGI1 on Neuronal Excitability.

Josefine Sell, Vahid Rahmati, Marin Kempfer, Sarosh R Irani, Andreas Ritzau-Jost, Stefan Hallermann, Christian Geis

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology(R) neuroimmunology & neuroinflammation, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Recent advances in autoantibody-mediated pain.Current opinion in supportive and palliative care · 2026
    Review
  4. Article
  5. Review
  6. Article
  7. Recent advances in autoimmune encephalitis.Arquivos de neuro-psiquiatria · 2024
    Review
  8. Article
  9. Review
  10. LGI1 Autoantibodies Enhance Synaptic Transmission by Presynaptic KNeurology(R) neuroimmunology & neuroinflammation · 2024
    Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 2 countries.

Josefine SellFrom the Section Translational Neuroimmunology (J.S., V.R., M.K., C.G.), Department of Neurology, Jena University Hospital, Germany; Oxford Autoimmune Neurology Group (S.R.I.), Nuffield Department of Clinical Neurosciences, University of Oxford, UK; Department of Neurology (S.R.I.), Oxford University Hospitals, UK; and Carl-Ludwig-Institute of Physiology (A.R.-J., S.H.), Faculty of Medicine, Leipzig University, Germany.
Vahid RahmatiFrom the Section Translational Neuroimmunology (J.S., V.R., M.K., C.G.), Department of Neurology, Jena University Hospital, Germany; Oxford Autoimmune Neurology Group (S.R.I.), Nuffield Department of Clinical Neurosciences, University of Oxford, UK; Department of Neurology (S.R.I.), Oxford University Hospitals, UK; and Carl-Ludwig-Institute of Physiology (A.R.-J., S.H.), Faculty of Medicine, Leipzig University, Germany.
Marin KempferFrom the Section Translational Neuroimmunology (J.S., V.R., M.K., C.G.), Department of Neurology, Jena University Hospital, Germany; Oxford Autoimmune Neurology Group (S.R.I.), Nuffield Department of Clinical Neurosciences, University of Oxford, UK; Department of Neurology (S.R.I.), Oxford University Hospitals, UK; and Carl-Ludwig-Institute of Physiology (A.R.-J., S.H.), Faculty of Medicine, Leipzig University, Germany.
Sarosh R IraniFrom the Section Translational Neuroimmunology (J.S., V.R., M.K., C.G.), Department of Neurology, Jena University Hospital, Germany; Oxford Autoimmune Neurology Group (S.R.I.), Nuffield Department of Clinical Neurosciences, University of Oxford, UK; Department of Neurology (S.R.I.), Oxford University Hospitals, UK; and Carl-Ludwig-Institute of Physiology (A.R.-J., S.H.), Faculty of Medicine, Leipzig University, Germany.ORCID 0000-0002-7667-9748
Andreas Ritzau-JostFrom the Section Translational Neuroimmunology (J.S., V.R., M.K., C.G.), Department of Neurology, Jena University Hospital, Germany; Oxford Autoimmune Neurology Group (S.R.I.), Nuffield Department of Clinical Neurosciences, University of Oxford, UK; Department of Neurology (S.R.I.), Oxford University Hospitals, UK; and Carl-Ludwig-Institute of Physiology (A.R.-J., S.H.), Faculty of Medicine, Leipzig University, Germany.
Stefan HallermannFrom the Section Translational Neuroimmunology (J.S., V.R., M.K., C.G.), Department of Neurology, Jena University Hospital, Germany; Oxford Autoimmune Neurology Group (S.R.I.), Nuffield Department of Clinical Neurosciences, University of Oxford, UK; Department of Neurology (S.R.I.), Oxford University Hospitals, UK; and Carl-Ludwig-Institute of Physiology (A.R.-J., S.H.), Faculty of Medicine, Leipzig University, Germany.ORCID 0000-0001-9376-7048
Christian GeisFrom the Section Translational Neuroimmunology (J.S., V.R., M.K., C.G.), Department of Neurology, Jena University Hospital, Germany; Oxford Autoimmune Neurology Group (S.R.I.), Nuffield Department of Clinical Neurosciences, University of Oxford, UK; Department of Neurology (S.R.I.), Oxford University Hospitals, UK; and Carl-Ludwig-Institute of Physiology (A.R.-J., S.H.), Faculty of Medicine, Leipzig University, Germany. christian.geis@med.uni-jena.de.
University of Oxford · GB

Funding

Department of HealthMedical Research Council MR/V007173/1Wellcome Trust 104079/Z/14/Z
6 · The paper itself

Abstract

BACKGROUND AND

objectivesAutoantibodies to leucine-rich glioma inactivated protein 1 (LGI1) cause an autoimmune limbic encephalitis with frequent focal seizures and anterograde memory dysfunction. LGI1 is a neuronal secreted linker protein with 2 functional domains: the leucine-rich repeat (LRR) and epitempin (EPTP) regions. LGI1 autoantibodies are known to interfere with presynaptic function and neuronal excitability; however, their epitope-specific mechanisms are incompletely understood.

methodsWe used patient-derived monoclonal autoantibodies (mAbs), which target either LRR or EPTP domains of LGI1 to investigate long-term antibody-induced alteration of neuronal function. LRR- and EPTP-specific effects were evaluated by patch-clamp recordings in cultured hippocampal neurons and compared with biophysical neuron modeling. K

resultsBoth EPTP and LRR domain-specific mAbs decreased the latency of first somatic action potential firing. However, only the LRR-specific mAbs increased the number of action potential firing together with enhanced initial instantaneous frequency and promoted spike-frequency adaptation, which were less pronounced after the EPTP mAb. This also led to an effective reduction in the slope of ramp-like depolarization in the subthreshold response, suggesting K DISCUSSION: These findings indicate an epitope-specific pathophysiology of LGI1 autoantibodies. The pronounced neuronal hyperexcitability and SFA together with dropped slope of ramp-like depolarization after LRR-targeted interference suggest disruption of LGI1-dependent clustering of K

Indexed as

Antibodies, MonoclonalIntracellular Signaling Peptides and ProteinsNeuronsAutoantibodiesAutoimmune DiseasesEpitopesHumansLeucineLimbic EncephalitisNerve Tissue ProteinsAntibodies, MonoclonalAutoantibodiesEpitopesIntracellular Signaling Peptides and ProteinsLeucineLGI1 protein, humanNerve Tissue Proteins

Identifiers

PMID37028941
PMCPMC10099296
OpenAlexW4362693647

What Socratic holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.