ArticleCardiovascular diabetology2023
Cardiovascular risk of metabolically healthy obesity in two european populations: Prevention potential from a metabolomic study.
Article in Cardiovascular diabetology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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26 citing papers in PubMed, 30 citations in OpenAlex.
- Metabolomic and lifestyle profiles refine BMI-metabolic phenotypes in older adults.Cell reports. Medicine · 2026Observational
- An adipocyte-endothelial framework to identify molecular signatures of metabolic vulnerability in obesity.Research square · 2026Article
- Extracellular Vesicles From Metabolically Healthy Obesity Convey Distinct Molecular Signals That Initiate Endothelial Dysfunction: A Multi-Omics Study in Adults of African Ancestry.bioRxiv : the preprint server for biology · 2026Article
- Circulating Adiponectin and Omentin Across Cardiometabolic Phenotypes: Links to Atherogenic Indices in Prediabetes and New-Onset Type 2 Diabetes.International journal of molecular sciences · 2026Article
- Association between albumin-bilirubin (ALBI) score and metabolically healthy obesity among US adults: findings from NHANES 2005-2018.BMC endocrine disorders · 2026Article
- Impact of metabolically healthy and metabolically unhealthy obesity on cardiac arrest and mortality in pulmonary embolism hospitalizations in elderly patients with cancer.Lung India : official organ of Indian Chest Society · 2026Article
- Association of healthy lifestyle with coronary artery disease risk varies by weight status: a prospective cohort study.Frontiers in nutrition · 2026Article
- Redefining cardiometabolic biomarkers in the big data era: toward a personalized medicine-centered reconstruction of risk prediction models.Frontiers in cardiovascular medicine · 2026Article
- Overweight or obesity and their association with cardiometabolic risk factors among oilfield workers in Chinese population: a cross-sectional study.Frontiers in public health · 2026Article
- Understanding the role of visceral fat in metabolically healthy versus unhealthy obesity: a sex-based analysis of the transcriptome.Biology of sex differences · 2025Article
- Different Metabolic Phenotypes of Obesity and 2 Decades Risk of Cardio-Renal-Metabolic Multimorbidity: Tehran Lipid and Glucose Study.Journal of the American Heart Association · 2025Article
- Association of Body Mass Index and Metabolic Health Status With Cerebrovascular Diseases in 617 755 Chinese Older People.Journal of the American Heart Association · 2025Article
- Metabolic health and cardiovascular disease across BMI categories: NHANES findings.Journal of health, population, and nutrition · 2025Article
- Inflammatory markers mediate the association between alternative adiposity indices and mortality in patients with rheumatoid arthritis: data from NHANES 1999-2018.Lipids in health and disease · 2025Article
- Association of metabolomic aging acceleration and body mass index phenotypes with mortality and obesity-related morbidities.Aging cell · 2025Article
- Obesity Phenotypes Causally Affect Cardiac MRI Structure and Induced Non-ischaemic Cardiomyopathy.Cardiac failure review · 2025Article
- Assessing metabolic health in a general population: A comparative analysis of three definitions in the Tromsø Study 2015-2016.PloS one · 2025Article
- Parents of children and adolescents knowledge, attitude, and practice toward metabolically healthy obesity: a cross-sectional survey.Frontiers in public health · 2025Article
- Associations of Metabolically Healthy Obesity and Retinal Age Gap.Translational vision science & technology · 2024Article
- Metabolically healthy obesity: from epidemiology and mechanisms to clinical implications.Nature reviews. Endocrinology · 2024Review
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Authors and funding
14 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA new definition of metabolically healthy obesity (MHO) has recently been proposed to stratify the heterogeneous mortality risk of obesity. Metabolomic profiling provides clues to metabolic alterations beyond clinical definition. We aimed to evaluate the association between MHO and cardiovascular events and assess its metabolomic pattern.
methodsThis prospective study included Europeans from two population-based studies, the FLEMENGHO and the Hortega study. A total of 2339 participants with follow-up were analyzed, including 2218 with metabolomic profiling. Metabolic health was developed from the third National Health and Nutrition Examination Survey and the UK biobank cohorts and defined as systolic blood pressure < 130 mmHg, no antihypertensive drugs, waist-to-hip ratio < 0.95 for women or 1.03 for men, and the absence of diabetes. BMI categories included normal weight, overweight, and obesity (BMI < 25, 25-30, ≥ 30 kg/m
resultsOf 2339 participants, the mean age was 51 years, 1161 (49.6%) were women, 434 (18.6%) had obesity, 117 (5.0%) were classified as MHO, and both cohorts had similar characteristics. Over a median of 9.2-year (3.7-13.0) follow-up, 245 cardiovascular events occurred. Compared to those with metabolically healthy normal weight, individuals with metabolic unhealthy status had a higher risk of cardiovascular events, regardless of BMI category (adjusted HR: 3.30 [95% CI: 1.73-6.28] for normal weight, 2.50 [95% CI: 1.34-4.66] for overweight, and 3.42 [95% CI: 1.81-6.44] for obesity), whereas those with MHO were not at increased risk of cardiovascular events (HR: 1.11 [95% CI: 0.36-3.45]). Factor analysis identified a metabolomic factor mainly associated with glucose regulation, which was associated with cardiovascular events (HR: 1.22 [95% CI: 1.10-1.36]). Individuals with MHO tended to present a higher metabolomic factor score than those with metabolically healthy normal weight (0.175 vs. -0.057, P = 0.019), and the score was comparable to metabolically unhealthy obesity (0.175 vs. -0.080, P = 0.91).
conclusionsIndividuals with MHO may not present higher short-term cardiovascular risk but tend to have a metabolomic pattern associated with higher cardiovascular risk, emphasizing a need for early intervention.
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