Evidence map›Paper›PMID 37030725›Full record

ArticleIEEE journal of biomedical and health informatics2023

Attention-Guided Autoencoder for Automated Progression Prediction of Subjective Cognitive Decline With Structural MRI.

Hao Guan, Ling Yue, Pew-Thian Yap, Shifu Xiao, Andrea Bozoki, Mingxia Liu

Open access · greenAbstract read
In one paragraph

Article in IEEE journal of biomedical and health informatics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Hybrid multi-modality multi-task learning for forecasting progression trajectories in subjective cognitive decline.Neural networks : the official journal of the International Neural Network Society · 2025
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Hao Guan
Ling Yue
Pew-Thian Yap
Shifu Xiao
Andrea Bozoki
Mingxia Liu
University of North Carolina at Chapel Hill · USShanghai Jiao Tong University · CN

Funding

Multi-Site Neuroimage Harmonization for Personalized Brain Disorder AnalysisRF1AG073297 · NIA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LIU, MINGXIA · 2022 to 2022
$1.4M
NIA NIH HHS RF1 AG073297
6 · The paper itself

Abstract

Subjective cognitive decline (SCD) is the preclinical stage of Alzheimer's disease (AD) which happens even earlier than mild cognitive impairment (MCI). Progressive SCD will convert to MCI with the potential of further evolving to AD. Therefore, early identification of progressive SCD with neuroimaging techniques (e.g., structural MRI) is of great clinical value for early intervention of AD. However, existing MRI-based machine/deep learning methods usually suffer the small-sample-size problem and lack interpretability. To this end, we propose an interpretable autoencoder model with domain transfer learning (IADT) for progression prediction of SCD. Firstly, the proposed model can leverage MRIs from both the target domain (i.e., SCD) and auxiliary domains (e.g., AD and NC) for progressive SCD identification. Besides, it can automatically locate the disease-related brain regions of interest (defined in brain atlases) through an attention mechanism, which shows good interpretability. In addition, the IADT model is straightforward to train and test with only 5  ∼ 10 seconds on CPUs and is suitable for medical tasks with small datasets. Extensive experiments on the publicly available ADNI dataset and a private CLAS dataset have demonstrated the effectiveness of the proposed method.

Indexed as

Alzheimer DiseaseCognitive DysfunctionBrainDisease ProgressionHumansMachine LearningMagnetic Resonance ImagingNeuroimaging

Identifiers

PMID37030725
PMCPMC10247503
OpenAlexW4327663252

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.