ArticleFrontiers in pediatrics2023
Skin-to-skin contact-An effective intervention on pain and stress reduction in preterm infants.
Article in Frontiers in pediatrics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06077409 (''The Effect of Skin-to-Skin Contact and Gentle Touch Method Applied During Blood Collection on Early Detection of Pain and Physiological Parameters''), which is not on this map. Cited by 16 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
''The Effect of Skin-to-Skin Contact and Gentle Touch Method Applied During Blood Collection on Early Detection of Pain and Physiological Parameters''
Who cites it
16 citing papers in PubMed, 3 syntheses or guidelines pooled it, 20 citations in OpenAlex.
- Neonatal pain assessment and non-pharmacological analgesia: an integrative literature review.Frontiers in pain research (Lausanne, Switzerland) · 2026Pooled it
- Assessment of cortisol as a neonatal pain biomarker in the application of non-pharmacological analgesia therapies: systematic review and meta-analysis.BMC pediatrics · 2025Pooled it
- Impact of skin-to-skin contact on acute procedural pain in newborns: a systematic review and meta-analysis.Jornal de pediatriaPooled it
- Effect of early skin-to-skin contact after vaginal birth on neonatal stress and day-5 bilirubin levels: a randomized trial.Scientific reports · 2026Trial
- Thermal stability during early skin-to-skin vs incubator care in infants born at 22-25 weeks' gestation: a non-inferiority prospective cohort study.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Article
- Breastfeeding in Tzeltal indigenous communities in Mexico: embodied and participatory experiences for policy recommendations.International breastfeeding journal · 2026Article
- Physiological correlates of pain in preterm infants: evidence from a meta-analytic approach.Frontiers in pediatrics · 2026Review
- A Comprehensive Evidence-Based Review of Non-Pharmaceutical Interventions for Neonatal Pain.Journal of pain research · 2026Review
- Exposure to clinical stressors during NICU admission in preterm infants.European journal of pediatrics · 2025Article
- Risk factors and short-term respiratory outcomes associated with unplanned extubations during neonatal intensive care.Frontiers in pediatrics · 2025Article
- Efficacy and safety of a novel hand dorsum intravenous indwelling needle fixation device in hospitalized pediatric patients: a retrospective controlled study.Frontiers in pediatrics · 2025Review
- Glucocorticosteroids and bronchopulmonary dysplasia : is epigenetics the missing link?Pediatric research · 2024Article
- The effect of live-performed music therapy with physical contact in preterm infants on parental perceived stress and salivary cortisol levels.Frontiers in psychology · 2024Article
- The relationship between neonatal stress in preterm infants and developmental outcomes at the corrected age of 24-30 months.Frontiers in psychology · 2024Article
- Parent-led neonatal pain management-a narrative review and update of research and practices.Frontiers in pain research (Lausanne, Switzerland) · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: The outcomes of pain and stress in preterm infants in the neonatal intensive care units (NICUs) compel the continued search for pain- and stress-reducing interventions. The objective of the study: To investigate how skin-to-skin contact (SSC) influences chronic pain and stress in preterm infants in the NICU. Materials and methods: The study included 140 preterm infants in the NICU with gestational age less than 34 weeks. The overall design was a baseline-response design. Urine and saliva were collected before (baseline) and after SSC to measure pain and stress markers by enzyme immunoassay method. The behavioral indicators of chronic pain were assessed using the EDIN (Échelle Douleur Inconfort Nouveau-Né-neonatal pain and discomfort). Results: There was a significant decrease in the dopamine level in preterm infants after SSC in comparison with baseline values (85.99 [69.35; 112.20] pg/ml vs. 132.20 [104.80; 183.70] pg/ml), Conclusion: Preterm infants in the NICU experience stress and pain, which were confirmed by the EDIN pain scale and laboratory markers. The level of dopamine and cortisol as pain and stress hormones were reliably high, and normalized after regular SSC. Simultaneously, pain-relieving and anti-stress markers of oxytocin, β-endorphin and serotonin reliably increased in preterm infants in response to the SSC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.