Evidence map›Paper›PMID 37034588›Full record

ArticleResearch square2023

Translatome analysis of Tuberous Sclerosis Complex-1 patient-derived neural progenitor cells reveal rapamycin-dependent and independent alterations.

Inci S Aksoylu, Pauline Martin, Francis Robert, Krzysztof J Szkop, Nicholas E Redmond, Shan Chen, Roberta L Beauchamp, Irene Nobeli, Jerry Pelletier, Ola Larsson and 1 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 4 countries.

Inci S AksoyluDepartment of Oncology-Pathology, Science for Life Laboratory, Karolinska Institute, Stockholm, Sweden.
Pauline MartinCtr. for Genomic Med., Department of Neurology, Massachusetts Gen. Hosp., Boston, MA.
Francis RobertDepartment of Biochem. and Goodman Cancer Res. Ctr., McGill Univ., Montreal, QC, Canada.
Krzysztof J SzkopDepartment of Oncology-Pathology, Science for Life Laboratory, Karolinska Institute, Stockholm, Sweden.
Nicholas E RedmondCtr. for Genomic Med., Department of Neurology, Massachusetts Gen. Hosp., Boston, MA.
Shan ChenDepartment of Oncology-Pathology, Science for Life Laboratory, Karolinska Institute, Stockholm, Sweden.
Roberta L BeauchampCtr. for Genomic Med., Department of Neurology, Massachusetts Gen. Hosp., Boston, MA.
Irene NobeliDepartment of Biol. Sciences, Inst. of Structural and Mol. Biology, Birkbeck, Univ. of London, London, United Kingdom.
Jerry PelletierDepartment of Biochem. and Goodman Cancer Res. Ctr., McGill Univ., Montreal, QC, Canada.ORCID 0000-0003-1963-6466
Ola LarssonDepartment of Oncology-Pathology, Science for Life Laboratory, Karolinska Institute, Stockholm, Sweden.ORCID 0000-0003-1412-1308
Vijaya RameshCtr. for Genomic Med., Department of Neurology, Massachusetts Gen. Hosp., Boston, MA.
Karolinska Institutet · SEMassachusetts General Hospital · USMcGill University · CABirkbeck, University of London · GB

Funding

Tuberous Sclerosis Complex Patients iPSC-derived NPCs and NCCs as Human Model Systems to Identify Novel TargetsR01NS109540 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI HAGGARTY, STEPHEN J, RAMESH, VIJAYA · 2019 to 2023
$2.5M
NINDS NIH HHS R01 NS109540Wellcome Trust
6 · The paper itself

Abstract

Tuberous sclerosis complex (TSC) is an inherited neurocutaneous disorder caused by mutations in

Identifiers

PMID37034588
PMCPMC10081384
OpenAlexW4361002984

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.