Evidence map›Paper›PMID 37035486›Full record

ArticleOpen forum infectious diseases2023

Antibody Response After Third Vaccination With mRNA-1273 or BNT162b2: Extension of a Randomized Controlled SARS-CoV-2 Noninferiority Vaccine Trial in Patients With Different Levels of Immunosuppression (COVERALL-2).

Alexandra Griessbach, Frédérique Chammartin, Irene A Abela, Patrizia Amico, Marcel P Stoeckle, Anna L Eichenberger, Barbara Hasse, Dominique L Braun, Macé M Schuurmans, Thomas F Müller and 16 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Open forum infectious diseases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Trial
  2. Review
  3. Review
  4. Observational
  5. Article
  6. Observational
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Alexandra GriessbachDivision of Clinical Epidemiology, Department of Clinical Research, University Hospital Basel and University of Basel, Basel, Switzerland.ORCID https://orcid.org/0000-0003-3726-1856
Frédérique ChammartinDivision of Clinical Epidemiology, Department of Clinical Research, University Hospital Basel and University of Basel, Basel, Switzerland.
Irene A AbelaInstitute of Medical Virology, University of Zurich, Zurich, Switzerland.
Patrizia AmicoClinic for Transplantation Immunology and Nephrology, University Hospital Basel, Basel, Switzerland.
Marcel P StoeckleDivision of Infectious Diseases and Hospital Epidemiology, University Hospital Basel, University of Basel, Basel, Switzerland.
Anna L EichenbergerDepartment of Infectious Diseases, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Barbara HasseDepartment of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Zurich, Switzerland.
Dominique L BraunInstitute of Medical Virology, University of Zurich, Zurich, Switzerland.
Macé M SchuurmansDivision of Pulmonology, University Hospital Zurich, Zurich, Switzerland.
Thomas F MüllerNephrology Clinic, University Hospital Zurich, Zurich, Switzerland.
Michael TammClinic of Respiratory Medicine and Pulmonary Cell Research, University Hospital Basel, Basel, Switzerland.
Annette AudigéInstitute of Medical Virology, University of Zurich, Zurich, Switzerland.
Nicolas J MuellerDepartment of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Zurich, Switzerland.
Andri RauchDepartment of Infectious Diseases, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Huldrych F GünthardInstitute of Medical Virology, University of Zurich, Zurich, Switzerland.
Michael T KollerClinic for Transplantation Immunology and Nephrology, University Hospital Basel, Basel, Switzerland.
Alexandra TrkolaInstitute of Medical Virology, University of Zurich, Zurich, Switzerland.
Selina EppInstitute of Medical Virology, University of Zurich, Zurich, Switzerland.
Alain AmstutzDivision of Clinical Epidemiology, Department of Clinical Research, University Hospital Basel and University of Basel, Basel, Switzerland.
Christof M SchönenbergerDivision of Clinical Epidemiology, Department of Clinical Research, University Hospital Basel and University of Basel, Basel, Switzerland.
Ala Taji HeraviDivision of Clinical Epidemiology, Department of Clinical Research, University Hospital Basel and University of Basel, Basel, Switzerland.
Katharina KusejkoInstitute of Medical Virology, University of Zurich, Zurich, Switzerland.ORCID https://orcid.org/0000-0002-4638-1940
Heiner C BucherDivision of Clinical Epidemiology, Department of Clinical Research, University Hospital Basel and University of Basel, Basel, Switzerland.
Matthias BrielDivision of Clinical Epidemiology, Department of Clinical Research, University Hospital Basel and University of Basel, Basel, Switzerland.ORCID https://orcid.org/0000-0002-2070-5230
Benjamin SpeichDivision of Clinical Epidemiology, Department of Clinical Research, University Hospital Basel and University of Basel, Basel, Switzerland.ORCID https://orcid.org/0000-0002-3301-8085
Swiss HIV Cohort Study and the Swiss Transplant Cohort Study

Funding

Swiss National Science Foundation 177499
6 · The paper itself

Abstract

Extension of the COVERALL (COrona VaccinE tRiAL pLatform) randomized trial showed noninferiority in antibody response of the third dose of Moderna mRNA-1273 vaccine (95.3% [95% confidence interval {CI}, 91.9%-98.7%]) compared to Pfizer-BioNTech BNT162b2 vaccine (98.1% [95% CI, 95.9%-100.0%]) in individuals with different levels of immunosuppression (difference, -2.8% [95% CI, -6.8% to 1.3%]).

Indexed as

HIVOrgan transplantrandomized trialSARS-CoV-2Vaccine

Identifiers

PMID37035486
PMCPMC10077822

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.