Evidence map›Paper›PMID 37035757›Full record

ArticleMediators of inflammation2023

circRNA_17725 Promotes Macrophage Polarization towards M2 by Targeting FAM46C to Alleviate Arthritis.

Chunjuan Yang, Biao Ni, Chaoran Li, Wenchang Sun, Zhangxue Wang, Hui Wang, Xinyue Hou, Shushan Yan, Xiaodong Wang, Donghua Xu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Mediators of inflammation, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. Review
  9. Review
  10. Article
  11. Review
  12. Article
  13. Review
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Chunjuan YangDepartment of Rheumatology of the First Affiliated Hospital & the First Clinical College, Weifang Medical University, Weifang 261000, China.
Biao NiCentral Laboratory of the First Affiliated Hospital & the First Clinical College, Weifang Medical University, Weifang 261000, China.
Chaoran LiDepartment of Rheumatology of the First Affiliated Hospital & the First Clinical College, Weifang Medical University, Weifang 261000, China.
Wenchang SunCentral Laboratory of the First Affiliated Hospital & the First Clinical College, Weifang Medical University, Weifang 261000, China.
Zhangxue WangDepartment of Rheumatology of the First Affiliated Hospital & the First Clinical College, Weifang Medical University, Weifang 261000, China.
Hui WangCentral Laboratory of the First Affiliated Hospital & the First Clinical College, Weifang Medical University, Weifang 261000, China.
Xinyue HouCentral Laboratory of the First Affiliated Hospital & the First Clinical College, Weifang Medical University, Weifang 261000, China.
Shushan YanDepartment of Gastrointestinal and Anal Diseases Surgery of the Affiliated Hospital, Weifang Medical University, Weifang 261000, China.ORCID https://orcid.org/0009-0006-2508-7861
Xiaodong WangDepartment of Rheumatology of the Affiliated Hospital, Weifang Medical University, Weifang 261000, China.ORCID https://orcid.org/0000-0003-4838-1466
Donghua XuDepartment of Rheumatology of the First Affiliated Hospital & the First Clinical College, Weifang Medical University, Weifang 261000, China.ORCID https://orcid.org/0000-0002-9146-7858
Weifang Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Accumulating studies have implicated that circular RNAs (circRNAs) play vital roles in the pathogenesis of rheumatoid arthritis (RA). Dysregulation of macrophage polarization leads to immune homeostatic imbalance in RA. However, the altering effects and mechanisms of circRNAs on macrophages polarization and immune homeostatic balance remain largely unclear. We aimed to investigate the potential role of circRNA_17725 in RA. The high-throughput sequence was performed to identify the dysregulated circRNAs in RA. We confirmed the data by CCK-8, EdU, and Annexin V/PI staining to elucidate the proliferation and apoptosis. The expressions of M1/M2-associated markers were confirmed using real-time PCR and flow cytometry analysis. Luciferase reporter assay and RNA Binding Protein Immunoprecipitation (RIP) were used to demonstrate the underlying mechanism of circRNA_17725. The altering effect of circRNA_17725 on macrophages in vivo was evaluated using collagen-induced arthritis (CIA) mouse model. circRNA_17725 was demonstrated to be downregulated in peripheral blood mononuclear cells and CD14

Indexed as

Arthritis, ExperimentalArthritis, RheumatoidMicroRNAsAnimalsLeukocytes, MononuclearMacrophagesMiceRNA, CircularMicroRNAsRNA, Circular

Identifiers

PMID37035757
PMCPMC10081909
OpenAlexW4362452800

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.