Evidence map›Paper›PMID 37037953›Full record

ArticlePediatric research2023

Estimation of skeletal muscle mass in 4-year-old children using the D

Aysha Sidiqi, Farzana Fariha, Shaila S Shanta, Alison Dasiewicz, Abdullah Al Mahmud, Daniel R Moore, Mahalakshmi Shankaran, Marc K Hellerstein, William J Evans, Alison D Gernand and 6 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Skeletal Muscle Mass Measured Noninvasively by DJournal of pediatrics. Clinical practice · 2025
    Article
  2. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 8 institutions in 5 countries.

Aysha SidiqiDepartment of Nutritional Sciences, University of Toronto, Toronto, ON, Canada.
Farzana FarihaNutrition and Clinical Services Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh.
Shaila S ShantaNutrition and Clinical Services Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh.
Alison DasiewiczCentre for Global Child Health, Hospital for Sick Children, Toronto, ON, Canada.
Abdullah Al MahmudNutrition and Clinical Services Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh.
Daniel R MooreFaculty of Kinesiology and Physical Education, University of Toronto, Toronto, ON, Canada.
Mahalakshmi ShankaranDepartment of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, CA, USA.
Marc K HellersteinDepartment of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, CA, USA.
William J EvansDepartment of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, CA, USA.
Alison D GernandDepartment of Nutritional Sciences, The Pennsylvania State University, University Park, PA, USA.
M Munirul IslamNutrition and Clinical Services Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh.
Steven A AbramsDepartment of Pediatrics, Dell Medical School at the University of Texas at Austin, Austin, TX, USA.
Jennifer HarringtonDepartment of Pediatrics, Women's and Children's Health Network and University of Adelaide, Adelaide, SA, Australia.
Edna NyangauDepartment of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, CA, USA.
Daniel E RothDepartment of Nutritional Sciences, University of Toronto, Toronto, ON, Canada.
Karen M O'CallaghanCentre for Global Child Health, Hospital for Sick Children, Toronto, ON, Canada. karen.ocallaghan@kcl.ac.uk.
International Centre for Diarrhoeal Disease Research · BDUniversity of California, Berkeley · USHospital for Sick Children · CAUniversity of Toronto · CAKing's College London · GBPennsylvania State University · USThe University of Texas at Austin · USUniversity of Adelaide · AU

Funding

CIHR OPP1176987CIHR PJT159596
6 · The paper itself

Abstract

backgroundGiven limited experience in applying the creatine-(methyl-D

methodsFollowing D

resultsSMM was measured successfully in 91% of participants, and there were no adverse events. Mean ± SD SMM was greater than ALM (4.5 ± 0.4 and 3.2 ± 0.6 kg, respectively). Precision of SMM was low (intraclass correlation = 0.20; 95% CI: 0.02, 0.75; n = 10). Grip strength was not associated with SMM in multivariable analysis (0.004 kg per 100 g of SMM; 95% CI: -0.031, 0.038; n = 91).

conclusionsThe D IMPACT: The D3-creatine (D3Cr) stable isotope dilution method was considered a feasible method for the estimation of skeletal muscle mass (SMM) in young children in a community setting and was well accepted among participants. SMM was weakly associated with both dual-energy x-ray absorptiometry-derived values of appendicular lean mass and grip strength. High within-child variability in estimated values of SMM suggests that further optimization of the D3Cr stable isotope dilution method is required prior to implementation in community research settings.

Indexed as

CreatineMuscle, SkeletalAbsorptiometry, PhotonBangladeshBody CompositionChild, PreschoolCreatinineHumansIsotopesCreatineCreatinineIsotopes

Identifiers

PMID37037953
PMCPMC10444613
OpenAlexW4363676056

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.