ArticleNature human behaviour2023
Brain structure, phenotypic and genetic correlates of reading performance.
Article in Nature human behaviour, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- Neural Cell Models of Specific Reading Disabilities: Identification of Cellular and Transcriptome Alterations.Genes, brain, and behavior · 2026Article
- Heritable and experience-dependent cortical traits of reading ability.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- From school climate to brain development: What the ABCD study reveals about the educational context of adolescence.Developmental cognitive neuroscience · 2026Review
- A decade of discovery: Leveraging genomic data in the ABCD study to illuminate adolescent neurodevelopment.Developmental cognitive neuroscience · 2026Review
- Does bilingualism buffer genetic predispositions to reading difficulties through alterations of structural interhemispheric connectivity? An ABCDbioRxiv : the preprint server for biology · 2026Article
- Toward an Improved Understanding of Dyslexia: Reflections on a New Consensus Definition and Its Implications.Dyslexia (Chichester, England) · 2026Article
- Bilateral Ventral Pathways Support Phonological Awareness at Reading Onset in Spanish-Speaking Children.Neurobiology of language (Cambridge, Mass.) · 2026Article
- Considerations for conducting developmental neuroimaging research on mental health topics.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Genetic underpinnings and causal effects of brain structure and function on chronic pain intensity.Nature communications · 2025Article
- Mediational effects of reading-related intermediate phenotypes from polygenic scores to reading skills.NPJ science of learning · 2025Article
- Longitudinal trajectories of brain development from infancy to school age and their relationship with literacy development.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Innate network mechanisms of temporal pole for semantic cognition in neonatal and adult twin studies.Nature communications · 2025Article
- Longitudinal trajectories of brain development from infancy to school age and their relationship to literacy development.bioRxiv : the preprint server for biology · 2025Article
- Processing Language Partly Shares Neural Genetic Basis with Processing Tools and Body Parts.eNeuro · 2024Article
- Unraveling individual differences in learning potential: A dynamic framework for the case of reading development.Developmental cognitive neuroscience · 2024Review
- Causal Relationships Between Screen Use, Reading, and Brain Development in Early Adolescents.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Neuroscience: genes, brains, and reading variability.Communications psychology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Reading is an evolutionarily recent development that recruits and tunes brain circuitry connecting primary- and language-processing regions. We investigated whether metrics of the brain's physical structure correlate with reading performance and whether genetic variants affect this relationship. To this aim, we used the Adolescent Brain Cognitive Development dataset (n = 9,013) of 9-10-year-olds and focused on 150 measures of cortical surface area (CSA) and thickness. Our results reveal that reading performance is associated with nine measures of brain structure including relevant regions of the reading network. Furthermore, we show that this relationship is partially mediated by genetic factors for two of these measures: the CSA of the entire left hemisphere and, specifically, of the left superior temporal gyrus CSA. These effects emphasize the complex and subtle interplay between genes, brain and reading, which is a partly heritable polygenic skill that relies on a distributed network.
Indexed as
Identifiers
37037991What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.