ArticleBrain communications2023
Spared speech fluency is associated with increased functional connectivity in the speech production network in semantic variant primary progressive aphasia.
Article in Brain communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 11 citations in OpenAlex.
- Cognitive reserve and longitudinal changes in brain and cognition in semantic variant primary progressive aphasia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Language deficits across PET-based Braak stages of tau accumulation in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- MULTI-OBJECT DATA INTEGRATION IN THE STUDY OF PRIMARY PROGRESSIVE APHASIA.The annals of applied statistics · 2025Article
- Network changes associated with right anterior temporal lobe atrophy: insight into unique symptoms.Brain communications · 2025Article
- Functional and Effective Connectivity Underlying Semantic Verbal Fluency.Brain topography · 2024Article
- Computer-Based Naming Treatment for Semantic Variant Primary Progressive Aphasia With History of Traumatic Brain Injury: A Single-Case Experimental Design.Journal of speech, language, and hearing research : JSLHR · 2024Article
- Breakdown of category-specific word representations in a brain-constrained neurocomputational model of semantic dementia.Scientific reports · 2023Article
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Authors and funding
16 authors at 7 institutions in 3 countries.
Funding
Abstract
Semantic variant primary progressive aphasia is a clinical syndrome characterized by marked semantic deficits, anterior temporal lobe atrophy and reduced connectivity within a distributed set of regions belonging to the functional network associated with semantic processing. However, to fully depict the clinical signature of semantic variant primary progressive aphasia, it is necessary to also characterize preserved neural networks and linguistic abilities, such as those subserving speech production. In this case-control observational study, we employed whole-brain seed-based connectivity on task-free MRI data of 32 semantic variant primary progressive aphasia patients and 46 healthy controls to investigate the functional connectivity of the speech production network and its relationship with the underlying grey matter. We investigated brain-behaviour correlations with speech fluency measures collected through clinical tests (verbal agility) and connected speech (speech rate and articulation rate). As a control network, we also investigated functional connectivity within the affected semantic network. Patients presented with increased connectivity in the speech production network between left inferior frontal and supramarginal regions, independent of underlying grey matter volume. In semantic variant primary progressive aphasia patients, preserved (verbal agility) and increased (articulation rate) speech fluency measures correlated with increased connectivity between inferior frontal and supramarginal regions. As expected, patients demonstrated decreased functional connectivity in the semantic network (dependent on the underlying grey matter atrophy) associated with average nouns' age of acquisition during connected speech. Collectively, these results provide a compelling model for studying compensation mechanisms in response to disease that might inform the design of future rehabilitation strategies in semantic variant primary progressive aphasia.
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