Evidence map›Paper›PMID 37039433›Full record

ArticleACS chemical biology2023

Identification of a Novel Small Molecule That Enhances the Release of Extracellular Vesicles with Immunostimulatory Potency via Induction of Calcium Influx.

Yukiya Sako, Fumi Sato-Kaneko, Nikunj M Shukla, Shiyin Yao, Masiel M Belsuzarri, Michael Chan, Tetsuya Saito, Fitzgerald S Lao, Helen Kong, Marina Puffer and 5 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS chemical biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 2 countries.

Yukiya SakoMoores Cancer Center, University of California San Diego, 9500 Gilman Dr, La Jolla, California 92093-0809, United States.ORCID 0000-0002-9279-1449
Fumi Sato-KanekoMoores Cancer Center, University of California San Diego, 9500 Gilman Dr, La Jolla, California 92093-0809, United States.
Nikunj M ShuklaMoores Cancer Center, University of California San Diego, 9500 Gilman Dr, La Jolla, California 92093-0809, United States.ORCID 0000-0002-5150-7827
Shiyin YaoMoores Cancer Center, University of California San Diego, 9500 Gilman Dr, La Jolla, California 92093-0809, United States.
Masiel M BelsuzarriMoores Cancer Center, University of California San Diego, 9500 Gilman Dr, La Jolla, California 92093-0809, United States.
Michael ChanMoores Cancer Center, University of California San Diego, 9500 Gilman Dr, La Jolla, California 92093-0809, United States.
Tetsuya SaitoMoores Cancer Center, University of California San Diego, 9500 Gilman Dr, La Jolla, California 92093-0809, United States.
Fitzgerald S LaoMoores Cancer Center, University of California San Diego, 9500 Gilman Dr, La Jolla, California 92093-0809, United States.
Helen KongMoores Cancer Center, University of California San Diego, 9500 Gilman Dr, La Jolla, California 92093-0809, United States.ORCID 0000-0002-5203-5497
Marina PufferMoores Cancer Center, University of California San Diego, 9500 Gilman Dr, La Jolla, California 92093-0809, United States.
Karen MesserThe Herbert Wertheim School of Public Health and Longevity, University of California San Diego, La Jolla, California 92093-0901, United States.
Minya PuThe Herbert Wertheim School of Public Health and Longevity, University of California San Diego, La Jolla, California 92093-0901, United States.
Howard B CottamMoores Cancer Center, University of California San Diego, 9500 Gilman Dr, La Jolla, California 92093-0809, United States.
Dennis A CarsonMoores Cancer Center, University of California San Diego, 9500 Gilman Dr, La Jolla, California 92093-0809, United States.
Tomoko HayashiMoores Cancer Center, University of California San Diego, 9500 Gilman Dr, La Jolla, California 92093-0809, United States.
University of California San Diego · USTokyo Medical and Dental University · JP

Funding

TO IDENTIFY NOVEL ADJUVANT CANDIDATES THAT CAN BE USED TO AUGMENT THE EFFICACY OF HUMAN VACCINES.75N93019C00042 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CARSON, DENNIS · 2019 to 2024
$10.2M
JEOL JEM-1400Plus Transmission Electron MicroscopeS10OD023527 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FARQUHAR, MARILYN GIST · 2017 to 2017
$579k
NIAID NIH HHS 75N93019C00042NIAID NIH HHS HHSN272201800048CNIH HHS S10 OD023527
6 · The paper itself

Abstract

Extracellular vesicles (EVs) transfer antigens and immunomodulatory molecules in immunologic synapses as a part of intracellular communication, and EVs equipped with immunostimulatory functions have been utilized for vaccine formulation. Hence, we sought small-molecule compounds that increase immunostimulatory EVs released by antigen-presenting dendritic cells (DCs) for enhancement of vaccine immunogenicity. We previously performed high-throughput screening on a 28K compound library using three THP-1 reporter cell lines with CD63 Turbo-Luciferase, NF-κB, and interferon-sensitive response element (ISRE) reporter constructs, respectively. Because intracellular Ca

Indexed as

CalciumExtracellular VesiclesImmunologic FactorsAnimalsImmunizationImmunogenicity, VaccineMiceSmall Molecule LibrariesCalciumImmunologic FactorsSmall Molecule Libraries

Identifiers

PMID37039433
PMCPMC10127211
OpenAlexW4364353719

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.