ArticleNature2023
Clonal haematopoiesis and risk of chronic liver disease.
Erratum issuedOpen access · greenAbstract read
In one paragraph
Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 135 papers, 4 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
135citing papers in PubMed, 4 pooled it
40.3field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
135 citing papers in PubMed, 4 syntheses or guidelines pooled it, 186 citations in OpenAlex.
- Pooled it
- Association of clonal haematopoiesis with heart failure incidence and outcomes: A systematic review and meta-analysis.European journal of heart failure · 2025Pooled it
- Clinical impact of clonal hematopoiesis in hematopoietic cell transplantation: a review, meta-analysis, and call to action.Haematologica · 2024Pooled it
- Clonal hematopoiesis of indeterminate potential as a prognostic factor: a systematic review and meta-analysis.Blood advances · 2024Pooled it
- Dynamics of clonal hematopoiesis under DNA-damaging treatment in patients with ovarian cancer.Leukemia · 2024Trial
- Article
- Predictive modeling of clonal hematopoiesis across diverse cohorts.Blood advances · 2026Article
- Clinical management of clonal hematopoiesis.Cancer · 2026Review
- The Evolution of Polyclonal Competition in Aging Hematopoiesis.Cancer discovery · 2026Article
- Exacerbation of inflammatory bone loss in TET2-driven clonal hematopoiesis.Journal of immunology (Baltimore, Md. : 1950) · 2026Article
- Clonal hematopoiesis of indeterminate potential and metabolic dysfunction-associated steatotic liver disease: Korean biopsy cohort.Hepatology international · 2026Article
- The MASLD-Cardio-Oncology Triangle: Dietary Patterns, Metabolic Remodelling and Implications for Cancer Therapy Tolerance.Nutrients · 2026Review
- Article
- Hematopoietic mosaic chromosomal alterations are pleiotropic drivers of inflammaging, multimorbidity, and mortality.medRxiv : the preprint server for health sciences · 2026Article
- Immunosenescence in systemic and multi-organ aging: mechanisms, inter-organ crosstalk, and translational opportunities.npj aging · 2026Review
- Current Understanding of CHIP's Immunobiological Footprint with A Focus on Gastrointestinal Disorders: A Review of the Literature.Current oncology reports · 2026Review
- Association Between Clonal Hematopoiesis and Cardiometabolic Disease: A Systematic Review and Meta-Analysis.JACC. CardioOncology · 2026Article
- Germline mutations and somatic mosaicism in steatotic liver diseases and related liver carcinogenesis.Nature reviews. Gastroenterology & hepatology · 2026Review
- Clonal haematopoiesis and cardiovascular disease, defining risk, filling gaps, and framing the future.NPJ cardiovascular health · 2026Review
- Article
75 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
37 authors at 20 institutions in 7 countries.
Waihay J Wong *Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.ORCID http://orcid.org/0000-0003-2023-6590
Connor Emdin *Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA.
Alexander G BickBroad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA.
Seyedeh M ZekavatBroad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA.ORCID http://orcid.org/0000-0003-4026-8944
Abhishek NiroulaDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
James P PirruccelloBroad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA.ORCID http://orcid.org/0000-0001-6088-4037
Laura DichtelNeuroendocrine Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Gabriel GriffinDepartment of Pathology, Brigham and Women's Hospital, Boston, MA, USA.
Md Mesbah UddinBroad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA.ORCID http://orcid.org/0000-0003-1846-0411
Christopher J GibsonDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.ORCID http://orcid.org/0000-0002-3700-5310
Veronica KovalcikDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Amy E LinDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Marie E McConkeyDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Amelie VrommanDivision of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0002-1724-2095
Rob S SellarDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Peter G KimDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.ORCID http://orcid.org/0000-0002-8716-8759
Mridul AgrawalDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Joshua WeinstockDepartment of Biostatistics, Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0001-7013-1899
Michelle T LongSection of Gastroenterology, Boston Medical Center, Boston University School of Medicine, Boston, MA, USA.ORCID http://orcid.org/0000-0001-6131-3981
Bing YuDepartment of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA.
Rajarshi BanerjeePerspectum Ltd, Oxford, UK.
Rowan C NichollsPerspectum Ltd, Oxford, UK.ORCID http://orcid.org/0000-0002-3311-4974
Andrea DennisPerspectum Ltd, Oxford, UK.
Matt KellyPerspectum Ltd, Oxford, UK.ORCID http://orcid.org/0000-0002-5834-635X
Po-Ru LohBroad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA.ORCID http://orcid.org/0000-0001-5542-9064
Steve McCarrollBroad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-6954-8184
Eric BoerwinkleHuman Genetics Center, Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Ramachandran S VasanThe University of Texas School of Public Health San Antonio, San Antonio, TX, USA.ORCID http://orcid.org/0000-0001-7357-5970
Siddhartha JaiswalDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-9597-0477
Andrew D JohnsonPopulation Sciences Branch, National Heart, Lung, and Blood Institute, Framingham, MA, USA.ORCID http://orcid.org/0000-0001-6369-5178
Raymond T ChungDepartment of Medicine, Harvard Medical School, Boston, MA, USA.
Kathleen CoreyDepartment of Medicine, Harvard Medical School, Boston, MA, USA.
Daniel LevyFramingham Heart Study of the NHLBI and Boston University School of Medicine, Framingham, MA, USA.ORCID http://orcid.org/0000-0003-1843-8724
Christie BallantyneDepartment of Medicine, Baylor College of Medicine, Houston, TX, USA.ORCID http://orcid.org/0000-0002-6432-1730
NHLBI TOPMed Hematology Working Group
Benjamin L EbertDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. Benjamin_Ebert@dfci.harvard.edu.ORCID http://orcid.org/0000-0003-0197-5451
Pradeep NatarajanBroad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA. pnatarajan@mgh.harvard.edu.ORCID http://orcid.org/0000-0001-8402-7435
Brigham and Women's Hospital · USUniversity of Washington · USBroad Institute · USBaylor College of Medicine · USJohns Hopkins University · USUniversity of Michigan · USNational Institutes of Health · USUniversity of Pittsburgh · USHarvard University · USUniversity of Maryland, College Park · USUniversity of North Carolina at Chapel Hill · USCleveland Clinic · USAtrium Health Wake Forest Baptist · USEmory University · USNew York Genome Center · USUniversity of Alabama · USUniversity of California, San Francisco · USDuke University · USThe University of Texas Rio Grande Valley · USUniversity of Mississippi · US
Funding
Framingham Project/LevyZIAHL006001 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI LEVY, DANIEL · 2009 to 2025
$51.1MUNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Hazel B Nichols · 2001 to 2026
$36.3MROLE OF DIETARY CONSTITUENTS ON GENE EXPRESSION IN INTESTINAL EPITHELIUMP30DK040561 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Elizabeth Austen Lawson, Takara Leah Stanley · 1994 to 2026
$31.6MMedical Scientist Training ProgramT32GM136651 · NIGMS · YALE UNIVERSITY · PI BARBARA I KAZMIERCZAK · 2020 to 2026
$16.5MPROTEOMICS CORE FACILITYG12MD007597 · NIMHD · HOWARD UNIVERSITY · PI SOUTHERLAND, WILLIAM M. · 2012 to 2018
$14.8MSystems Biology of Airway DiseaseP01HL132825 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI WEISS, SCOTT T · 2016 to 2020
$12.6MTargeting SYK Kinase in AMLP50CA206963 · NCI · DANA-FARBER CANCER INST · PI GRAUBERT, TIMOTHY A · 2017 to 2021
$10.6MStudies of Rare Genetic Variation in the Isolated Population of SardiniaR01HL117626 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ABECASIS, GONCALO · 2013 to 2016
$10.5MTyrosine Kinases, Serine-Threonine Kinases,&Phosophatases in PathogenesisP01CA108631 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI BERRY, DONALD A · 2005 to 2009
$9.7MRare variants and NHLBI traits in deeply phenotyped cohortsR01HL120393 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M, RICE, KENNETH M. · 2014 to 2016
$8.9MFunctional Genomic Dissection of Refractory AnemiaR01HL082945 · NHLBI · DANA-FARBER CANCER INSTITUTE · PI EBERT, BENJAMIN LEVINE · 2005 to 2022
$6.8MClonal hematopoiesis in the Womens Health Initiative Memory StudyR01HL148565 · NHLBI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI ALEXANDER P REINER, Eric A. Whitsel · 2019 to 2026
$5.9MNCI NIH HHS K08 CA263555NCI NIH HHS P01 CA108631NCI NIH HHS P50 CA206963NCI NIH HHS R35 CA253125NHLBI NIH HHS DP2 HL157540NHLBI NIH HHS F30 HL149180NHLBI NIH HHS HHSN268201800001CNHLBI NIH HHS K08 HL159346NHLBI NIH HHS P01 HL132825NHLBI NIH HHS R01 HL082945NHLBI NIH HHS R01 HL117626NHLBI NIH HHS R01 HL120393NHLBI NIH HHS R01 HL139865NHLBI NIH HHS R01 HL142711NHLBI NIH HHS R01 HL148050NHLBI NIH HHS R01 HL148565NHLBI NIH HHS U01 HL120393NIAID NIH HHS R01 AI136715NIAID NIH HHS R01 AI155140NIA NIH HHS K01 AG059898NIDDK NIH HHS K23 DK113220NIDDK NIH HHS P30 DK040561NIDDK NIH HHS R01 DK125782NIEHS NIH HHS DP2 ES030554NIEHS NIH HHS P30 ES010126NIGMS NIH HHS T32 GM136651NIH HHS S10 OD026880NIH HHS S10 OD030463NIMHD NIH HHS G12 MD007597
Abstract
Chronic liver disease is a major public health burden worldwide
Indexed as
Clonal HematopoiesisDisease SusceptibilityHepatitisLiver CirrhosisAnimalsDioxygenasesDisease ProgressionDNA-Binding ProteinsInflammationMiceNLR Family, Pyrin Domain-Containing 3 ProteinNon-alcoholic Fatty Liver DiseaseOdds RatioDioxygenasesDNA-Binding ProteinsNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, mouseTet2 protein, mouse
Identifiers
What Socratic holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.