Trial reportJournal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance2023
Cardiovascular magnetic resonance-derived left atrioventricular coupling index and major adverse cardiac events in patients following acute myocardial infarction.
Trial report in Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 41 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Prospective Randomized Controlled Clinical Study to Compare Abciximab-bolus i.v. Versus i.c. in Primary PCI in Patients With Acute ST-elevation Myocardial Infarction
Thrombus Aspiration in ThrOmbus Containing culpRiT Lesions in Non-ST-Elevation Myocardial Infarction (TATORT-NSTEMI)
Who cites it
41 citing papers in PubMed, 47 citations in OpenAlex.
- Left atrioventricular coupling index in patients undergoing cardiac resynchronization therapy.The international journal of cardiovascular imaging · 2026Trial
- Cardiovascular magnetic resonance-derived left atrioventricular coupling index for predicting adverse cardiac outcomes in patients with ischemic cardiomyopathy.International journal of cardiology. Cardiovascular risk and prevention · 2026Article
- The Diagnostic and Prognostic Impact of Cardiovascular Magnetic Resonance in Ischemic Heart Disease: A Systematic Review.Journal of clinical medicine · 2026Review
- Diagnostic and prognostic value of left atrioventricular coupling index post revascularization in acute coronary syndrome: A two-dimensional echocardiographic study.Clinical physiology and functional imaging · 2026Article
- Editorial for "Prognostic Value of a Cardiac Magnetic Resonance-Derived Left Atrioventricular Coupling Index From Routine Cine Images in Dilated Cardiomyopathy: A Multicenter Study".Journal of magnetic resonance imaging : JMRI · 2026Article
- Cardiac magnetic resonance-derived left atrioventricular coupling index predicts outcome in reduced ejection fraction.ESC heart failure · 2026Article
- Sex-Specific Prognostic Value of Left Atrioventricular Coupling Index in Acute Coronary Syndrome: Insights From Artificial Intelligence-Enhanced 3-Dimensional Echocardiography.Journal of the American Heart Association · 2026Article
- Left atrioventricular coupling index by 2D and 3D echocardiography: association with exercise capacity in chronic kidney disease.Quantitative imaging in medicine and surgery · 2026Article
- Left Atrioventricular Coupling Index: A Comprehensive Review of the Literature.Life (Basel, Switzerland) · 2026Review
- Prognostic value of left atrioventricular coupling index in non-ischemic dilated cardiomyopathy: a cardiovascular magnetic resonance study.BMC cardiovascular disorders · 2026Article
- Prognostic value of the left atrioventricular coupling index for adverse cardiac outcomes in hypertrophic cardiomyopathy.International journal of cardiology. Cardiovascular risk and prevention · 2026Article
- CMR-quantified epicardial adipose tissue heterogeneity and its predictive value for ventricular and atrial arrhythmias after myocardial infarction.BMC medical imaging · 2026Article
- Left Atrioventricular Coupling Index Predicts Poor Prognosis in Acute Myocardial Infarction: A Single-Center Cohort Study.Journal of cardiovascular development and disease · 2026Article
- Left atrioventricular coupling in isolated pediatric mitral valve prolapse with preserved ejection fraction and moderate regurgitation.Scientific reports · 2026Article
- Prognostic impact of cardiovascular magnetic resonance-derived left atrioventricular coupling Index in patients with severe aortic stenosis undergoing transcatheter aortic valve replacement.European heart journal. Imaging methods and practice · 2026Article
- Clinical and cardiac magnetic resonance imaging features for differentiation between acute myocardial infarction with and without obstructive coronary arteries.Quantitative imaging in medicine and surgery · 2026Article
- Association of type 2 diabetes with left atrioventricular coupling and myocardial deformation in hypertension: a 3.0 T cardiac magnetic resonance study.Frontiers in cardiovascular medicine · 2026Article
- Echocardiographic assessment of left atrioventricular coupling index: technical approaches and clinical implementation strategies.Frontiers in cardiovascular medicine · 2026Review
- Establishment and validation of a machine learning-based predictive model for in-hospital mortality risk in acute myocardial infarction patients complicated with diabetes mellitus.Frontiers in cardiovascular medicine · 2026Article
- Left atrial-ventricular coupling index associated with new-onset atrial fibrillation in ST-segment elevation myocardial infarction patients.BMC cardiovascular disorders · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRecently, a novel left atrioventricular coupling index (LACI) has been introduced providing prognostic value to predict cardiovascular events beyond common risk factors in patients without cardiovascular disease. Since data on cardiovascular magnetic resonance (CMR)-derived LACI in patients following acute myocardial infarction (AMI) are scarce, we aimed to assess the diagnostic and prognostic implications of LACI in a large AMI patient cohort.
methodsIn total, 1046 patients following AMI were included. After primary percutaneous coronary intervention CMR imaging and subsequent functional analyses were performed. LACI was defined by the ratio of the left atrial end-diastolic volume divided by the left ventricular (LV) end-diastolic volume. Major adverse cardiac events (MACE) including death, reinfarction or heart failure within 12 months after the index event were defined as primary clinical endpoint.
resultsLACI was significantly higher in patients with MACE compared to those without MACE (p < 0.001). Youden Index identified an optimal LACI cut-off at 34.7% to classify patients at high-risk (p < 0.001 on log-rank testing). Greater LACI was associated with MACE on univariate regression modeling (HR 8.1, 95% CI 3.4-14.9, p < 0.001) and after adjusting for baseline confounders and LV ejection fraction (LVEF) on multivariate regression analyses (HR 3.1 95% CI 1.0-9, p = 0.049). Furthermore, LACI assessment enabled further risk stratification in high-risk patients with impaired LV systolic function (LVEF ≤ 35%; p < 0.001 on log-rank testing).
conclusionAtrial-ventricular interaction using CMR-derived LACI is a superior measure of outcome beyond LVEF especially in high-risk patients following AMI. Trial registration ClinicalTrials.gov, NCT00712101 and NCT01612312.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.