Evidence map›Paper›PMID 37046490›Full record

ArticleDiagnostics (Basel, Switzerland)2023

Sun-Exposed versus Sun-Protected Cutaneous Basal Cell Carcinoma: Clinico-Pathological Profile and p16 Immunostaining.

Abdulkarim Hasan, Ahmad M Kandil, Hasan S Al-Ghamdi, Mohammad A Alghamdi, Mohamed Nasr, Suhaib Alsayed Naeem, Wagih M Abd-Elhay, Osama Khalil E Mohamed, Hany Sabry A Ibrahim, Eman Mohamed Ahmed and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diagnostics (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Abdulkarim HasanPathology Department, Faculty of Medicine, Al-Azhar University, Cairo 11884, Egypt.ORCID 0000-0003-0391-306X
Ahmad M KandilPathology Department, Faculty of Medicine, Al-Azhar University, Cairo 11884, Egypt.
Hasan S Al-GhamdiInternal Medicine Department, Division of Dermatology, Faculty of Medicine, Albaha University, Albaha 65799, Saudi Arabia.
Mohammad A AlghamdiInternal Medicine Department, Division of Dermatology, Faculty of Medicine, Albaha University, Albaha 65799, Saudi Arabia.
Mohamed NasrHistology Department, Faculty of Medicine, Al-Azhar University, Cairo 11884, Egypt.
Suhaib Alsayed NaeemHistology Department, Faculty of Medicine, Al-Azhar University, Cairo 11884, Egypt.
Wagih M Abd-ElhayHistology Department, Faculty of Medicine, Al-Azhar University, Cairo 11884, Egypt.
Osama Khalil E MohamedDermatology, Venerology and Andrology Department, Faculty of Medicine, Al-Azhar University, Cairo 11884, Egypt.
Hany Sabry A IbrahimDermatology, Venerology and Andrology Department, International Islamic Center of Population Studies and Research, Al-Azhar University, Cairo 11651, Egypt.
Eman Mohamed AhmedPathology Department, Faculty of Medicine for Girls, Al-Azhar University, Cairo 11884, Egypt.
Ahmed Elsayed M AbdraboCommunity and Industrial Medicine Department, Faculty of Medicine, Al-Azhar University, Cairo 11884, Egypt.
Shimaa Abdelraouf ElgoharyPathology Department, Faculty of Medicine, Ain Shams University, Cairo 11517, Egypt.
Al-Azhar University · EGAl Baha University · SAAin Shams University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionAlthough widespread, BCC is still relatively poorly understood in regards to pathogenesis and prognosis, particularly the lesions formed on anatomical sites away from sun exposure. With the aim of deepening our understanding of the pathogenesis and clinico-pathological correlations of BCCs, we conducted this study.

methodsTissue blocks and data of 52 Egyptian patients diagnosed with BCC were retrieved for clinical information and inclusion criteria, then re-examined histologically; p16 immunostaining was carried out and evaluated for analysis and comparison between the two groups, i.e., sun-exposed and sun-protected.

resultsSex, age, clinical suspicion, tumor size, recurrence status, and histologic variants did not show a significant difference between the sun-protected and sun-exposed groups; however, the mean ages recorded were 67.2 vs. 62.7 for the sun-protected and sun-exposed groups, respectively. A total of 52% of BCCs were positive for p16. The sun-protected lesions showed p16 positivity in 61% of cases, whereas 49% of the sun-exposed lesions were positive with no significant difference. There was a significant difference in p16 expression between the recurrent and non-recurrent lesions.

conclusionsA significant difference was seen in the case of cancer recurrence, where all the recurrent BCCs in this study demonstrated negative p16 immunostaining of the primary lesions; however, the positively stained cases in total were 52% of BCCs. The mean patient age of the sun-protected group was much higher than in previous peer studies. We assume that the biological, prognostic, and clinical aspects of p16 protein expression in BCCs are still far from being clearly understood. Further studies are highly recommended, with more focus on its role in the pathogenesis and the prognostic factors.

Indexed as

basal cell carcinomaimmunohistochemistrynon-melanomcyticp16skin cancer

Identifiers

PMID37046490
PMCPMC10093321
OpenAlexW4361207656

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.