Evidence map›Paper›PMID 37047136›Full record

ArticleInternational journal of molecular sciences2023

Benzo[a]pyrene Exposure Reduces Cell-Type Diversity and Stimulates Sex-Biased Damage Pathways in End Organs of Lupus-Prone Mice.

Runqi Zhu, Kameron Kennicott, Yun Liang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Runqi ZhuDepartment of Physiology, Michigan State University, East Lansing, MI 48823, USA.ORCID 0009-0005-6891-3441
Kameron KennicottDepartment of Physiology, Michigan State University, East Lansing, MI 48823, USA.ORCID 0000-0003-4104-9719
Yun LiangDepartment of Physiology, Michigan State University, East Lansing, MI 48823, USA.
Michigan State University · US

Funding

Understanding the immunometabolic mechanism of VGLL3 mediating female-biased autoimmunityR01AR078781 · NIAMS · UNIVERSITY OF WISCONSIN-MADISON · PI Yun Liang · 2022 to 2026
$1.7M
The Role of VGLL3 in Sexually Dimorphic Interferon-Driven InflammationK01AR073340 · NIAMS · UNIVERSITY OF WISCONSIN-MADISON · PI LIANG, YUN · 2018 to 2023
$427k
Discovering miR6891-5p: guardian of XX allelic balance and barrier to Sjögren’s syndrome pathogenesisR21DE031765 · NIDCR · UNIVERSITY OF WISCONSIN-MADISON · PI LIANG, YUN · 2022 to 2023
$425k
NIAMS NIH HHS K01 AR073340NIAMS NIH HHS R01 AR078781NIDCR NIH HHS R21 DE031765NIH HHS K01 AR073340NIH HHS R01 AR078781NIH HHS R21 DE031765
6 · The paper itself

Abstract

Studies indicate that genetic factors only account for approximately thirty percent of all autoimmune diseases, while the rest of autoimmune pathogenesis is attributed to environmental factors including toxic chemicals. To understand if and how environmental pollutants trigger autoimmunity, we investigated the effect of benzo[a]pyrene (BaP) exposure on the development of autoimmune phenotypes in the lupus-prone MRL strain. The exposure of MRL mice to BaP over the course of 8 weeks before lupus onset resulted in total body weight loss in males, while marginal changes in anti-dsDNA levels occurred. Multi-organ analyses of BaP-treated and control MRL mice suggested that the kidney is a major organ directly affected by the metabolism of benzene-containing compounds, with increased expression of BaP-target genes including

Indexed as

Benzo(a)pyreneRenal InsufficiencyAnimalsFemaleGene Expression ProfilingKidneyMaleMiceSpleenBenzo(a)pyreneautoimmune diseasesenvironmental exposuremolecular mechanismsex differences

Identifiers

PMID37047136
PMCPMC10093912
OpenAlexW4360854423

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.