Evidence map›Paper›PMID 37047185›Full record

ReviewInternational journal of molecular sciences2023

The Role of MicroRNA in the Pathogenesis of Diabetic Nephropathy.

Joanna Szostak, Anna Gorący, Damian Durys, Paweł Dec, Andrzej Modrzejewski, Andrzej Pawlik

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Joanna SzostakDepartment of Physiology, Pomeranian Medical University, 70-111 Szczecin, Poland.
Anna GorącyDepartment of Physiology, Pomeranian Medical University, 70-111 Szczecin, Poland.
Damian DurysDepartment of Physiology, Pomeranian Medical University, 70-111 Szczecin, Poland.
Paweł DecPlastic and Reconstructive Surgery Department, 109 Military Hospital, 71-422 Szczecin, Poland.ORCID 0000-0002-8514-3259
Andrzej ModrzejewskiDepartment of Surgery, Pomeranian Medical University, 71-422 Szczecin, Poland.
Andrzej PawlikDepartment of Physiology, Pomeranian Medical University, 70-111 Szczecin, Poland.ORCID 0000-0001-6557-1208

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetic nephropathy is one of the most common and severe complications of diabetes mellitus, affecting one in every five patients suffering from diabetes. Despite extensive research, the exact pathogenesis of diabetic nephropathy is still unclear. Several factors and pathways are known to be involved in the development of the disease, such as reactive oxygen species or the activation of the renin-angiotensin-aldosterone system. The expression of those proteins might be extensively regulated by microRNA. Recent research suggests that in diabetic nephropathy patients, the profile of miRNA is significantly changed. In this review, we focus on the actions of miRNA in various pathways involved in the pathogenesis of diabetic nephropathy and the clinical usage of miRNAs as biomarkers and therapeutic targets.

Indexed as

Diabetes MellitusDiabetic NephropathiesMicroRNAsHumansReactive Oxygen SpeciesRenin-Angiotensin SystemMicroRNAsReactive Oxygen Speciesbiomarkersdiabetes mellitusdiabetic nephropathymicroRNAoxidative stresstransforming growth factor beta

Identifiers

PMID37047185
PMCPMC10094215

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.