Evidence map›Paper›PMID 37047229›Full record

Observational studyInternational journal of molecular sciences2023

Decreased Gas6 and sAxl Plasma Levels Are Associated with Hair Loss in COVID-19 Survivors.

Daria Apostolo, Davide D'Onghia, Stelvio Tonello, Rosalba Minisini, Alessio Baricich, Carla Gramaglia, Filippo Patrucco, Patrizia Zeppegno, Antonio Acquaviva, Piero Emilio Balbo and 19 more

Open access · goldAbstract readObservational Study
In one paragraph

Observational study in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors at 2 institutions in 1 country.

Daria ApostoloDepartment of Translational Medicine, Università del Piemonte Orientale (UPO), 28100 Novara, Italy.ORCID 0000-0002-2416-7468
Davide D'OnghiaDepartment of Translational Medicine, Università del Piemonte Orientale (UPO), 28100 Novara, Italy.ORCID 0000-0002-3196-940X
Stelvio TonelloDepartment of Translational Medicine, Università del Piemonte Orientale (UPO), 28100 Novara, Italy.ORCID 0000-0002-0836-0890
Rosalba MinisiniDepartment of Translational Medicine, Università del Piemonte Orientale (UPO), 28100 Novara, Italy.ORCID 0000-0002-7548-9731
Alessio BaricichDepartment of Translational Medicine, Università del Piemonte Orientale (UPO), 28100 Novara, Italy.ORCID 0000-0001-8440-6283
Carla GramagliaDepartment of Translational Medicine, Università del Piemonte Orientale (UPO), 28100 Novara, Italy.
Filippo PatruccoDepartment of Translational Medicine, Università del Piemonte Orientale (UPO), 28100 Novara, Italy.ORCID 0000-0002-4794-8734
Patrizia ZeppegnoDepartment of Translational Medicine, Università del Piemonte Orientale (UPO), 28100 Novara, Italy.
Antonio AcquavivaDepartment of Translational Medicine, Università del Piemonte Orientale (UPO), 28100 Novara, Italy.
Piero Emilio BalboA.O.U. Maggiore della Carità, 28100 Novara, Italy.
Luigi Mario CastelloDepartment of Translational Medicine, Università del Piemonte Orientale (UPO), 28100 Novara, Italy.ORCID 0000-0001-8248-1976
Giuseppe CappellanoDepartment of Translational Medicine, Università del Piemonte Orientale (UPO), 28100 Novara, Italy.ORCID 0000-0001-5193-4688
Annalisa ChiocchettiDepartment of Translational Medicine, Università del Piemonte Orientale (UPO), 28100 Novara, Italy.ORCID 0000-0002-4349-1087
Chiara GereviniDepartment of Translational Medicine, Università del Piemonte Orientale (UPO), 28100 Novara, Italy.
Mara GiordanoDepartment of Translational Medicine, Università del Piemonte Orientale (UPO), 28100 Novara, Italy.ORCID 0000-0001-6686-4600
Fatiha LaaguidDepartment of Translational Medicine, Università del Piemonte Orientale (UPO), 28100 Novara, Italy.
Marcello ManfrediDepartment of Translational Medicine, Università del Piemonte Orientale (UPO), 28100 Novara, Italy.
Davide RaineriDepartment of Translational Medicine, Università del Piemonte Orientale (UPO), 28100 Novara, Italy.ORCID 0000-0003-3327-6305
Cristina RigamontiDepartment of Translational Medicine, Università del Piemonte Orientale (UPO), 28100 Novara, Italy.ORCID 0000-0003-2089-4139
Roberta RollaDepartment of Translational Medicine, Università del Piemonte Orientale (UPO), 28100 Novara, Italy.ORCID 0000-0003-0805-8285
Valentina RomanoDepartment of Translational Medicine, Università del Piemonte Orientale (UPO), 28100 Novara, Italy.
Marco ConfalonieriPulmonology Department, University of Trieste, 34128 Trieste, Italy.ORCID 0000-0002-4791-768X
Paola SavoiaDepartment of Health Science, Università del Piemonte Orientale (UPO), 28100 Novara, Italy.ORCID 0000-0002-1636-8411
Elisa ZavattaroDepartment of Health Science, Università del Piemonte Orientale (UPO), 28100 Novara, Italy.ORCID 0000-0003-4537-3014
Mario PirisiDepartment of Translational Medicine, Università del Piemonte Orientale (UPO), 28100 Novara, Italy.ORCID 0000-0001-9740-0155
Barbara RuaroPulmonology Department, University of Trieste, 34128 Trieste, Italy.ORCID 0000-0001-8990-859X
Pier Paolo SainaghiDepartment of Translational Medicine, Università del Piemonte Orientale (UPO), 28100 Novara, Italy.ORCID 0000-0001-8322-9158
Mattia BellanDepartment of Translational Medicine, Università del Piemonte Orientale (UPO), 28100 Novara, Italy.ORCID 0000-0003-1488-8736
No-More COVID Group
Università degli Studi del Piemonte Orientale “Amedeo Avogadro” · ITUniversity of Trieste · IT

Funding

Fondazione Cariplo 2021-1541"Piano Riparti Piemonte", Azione n. 173 "INFRA-P. Realizzazione, rafforzamento e ampliamento Infrastrutture di ricerca pubbliche-bando" INFRA-P2-TECHNOMED-HUB 378-48
6 · The paper itself

Abstract

Post-acute conditions after coronavirus disease 2019 (COVID-19) are quite common, although the underlying pathogenetic mechanisms leading to these conditions are not yet completely understood. In this prospective observational study, we aimed to test the hypothesis that Growth Arrest-Specific 6 (Gas6) and its soluble receptors, Axl (sAxl) and MerTK (sMer), might be implicated. A total of 263 subjects underwent a structured clinical evaluation one year after their hospital discharge for COVID-19, and they consented to donate a blood sample to measure their circulating Gas6, sAxl, and sMer levels. A total of 98 (37.3%) post-COVID-19 subjects complained of at least one residual physical symptom one year after their hospital discharge. Univariate analysis revealed that sAxl was marginally associated with residual symptoms, but at the level of logistic regression analysis, only the diffusing capacity of the lungs for carbon monoxide (DLCO) (OR 0.98, CI 95%: 0.96-0.99;

Indexed as

COVID-19Proto-Oncogene Proteinsc-Mer Tyrosine KinaseFemaleGrowth Arrest-Specific Protein 6HumansIntercellular Signaling Peptides and ProteinsReceptor Protein-Tyrosine Kinasesc-Mer Tyrosine KinaseGrowth Arrest-Specific Protein 6Intercellular Signaling Peptides and ProteinsProto-Oncogene ProteinsReceptor Protein-Tyrosine KinasesGas6hair lossinflammationpost-acute COVID-19TAM receptor

Identifiers

PMID37047229
PMCPMC10094682
OpenAlexW4361007075

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.