SynthesisInternational journal of molecular sciences2023
Physiological Rhythms and Biological Variation of Biomolecules: The Road to Personalized Laboratory Medicine.
Synthesis in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed.
- Potential and pitfalls of personal reference intervals in general practice: A focus group and case vignette study among Dutch general practitioners.The European journal of general practice · 2026Article
- Review
- Circadian rhythms and non-coding RNAs: mechanistic insights, clinical impact, and future opportunities for personalized medicine.Cancer cell international · 2026Review
- Significance of sampling time on thyroid-stimulating hormone, free thyroxine, and free triiodothyronine levels.Journal of medical biochemistry · 2026Article
- Nocturnal Autonomic Nervous System Dynamics and Chronic Painful Temporomandibular Disorders.JDR clinical and translational research · 2026Observational
- Differential effects of sex and age on daily and infradian rhythms of mice.The Journal of physiology · 2026Article
- Circannual Rhythms Affect the Bioavailability of Phenolic Compounds from Grape Seed Proanthocyanidins Extract Differently in Healthy and Obese Fischer 344 Rats.Journal of agricultural and food chemistry · 2025Article
- The challenge of ecological validity in temporomandibular disorders research.Journal of oral rehabilitation · 2025Review
- Site- and cell-type-specific miRNA and mRNA genes and networks across the cortex, striatum, and hypothalamus.Communications biology · 2025Article
- Diurnal Effects on the Fraction of Fetal Cell-Free DNA in Maternal Plasma.Prenatal diagnosis · 2025Article
- Therapeutic potential of ginsenosides in circadian rhythm-based skin disorders.Journal of ginseng research · 2025Review
- Data science applied to the assessment of biological variation estimates.Advances in laboratory medicine · 2025Article
- Article
- The clinical impact of chronopharmacology on current medicine.Naunyn-Schmiedeberg's archives of pharmacology · 2025Review
- Are Your Laboratory Data Reproducible? The Critical Role of Imprecision from Replicate Measurements to Clinical Decision-making.Annals of laboratory medicine · 2025Review
- Monitoring Mouse Surface Temperature During Stress with a Thermal Camera: A Low-Cost Infrared Videography System for Evaluating Murine Metabolism.Current protocols · 2025Article
- Wearables in Chronomedicine and Interpretation of Circadian Health.Diagnostics (Basel, Switzerland) · 2025Review
- Development and validation of a prostate cancer risk prediction model for the elevated PSA population.Frontiers in oncology · 2025Article
- Keratoconus: A Probe Into the Refractive Symmetry.Journal of ophthalmology · 2025Article
- Circadian rhythms and cancer: implications for timing in therapy.Discover oncology · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The concentration of biomolecules in living systems shows numerous systematic and random variations. Systematic variations can be classified based on the frequency of variations as ultradian (<24 h), circadian (approximately 24 h), and infradian (>24 h), which are partly predictable. Random biological variations are known as between-subject biological variations that are the variations among the set points of an analyte from different individuals and within-subject biological variation, which is the variation of the analyte around individuals' set points. The random biological variation cannot be predicted but can be estimated using appropriate measurement and statistical procedures. Physiological rhythms and random biological variation of the analytes could be considered the essential elements of predictive, preventive, and particularly personalized laboratory medicine. This systematic review aims to summarize research that have been done about the types of physiological rhythms, biological variations, and their effects on laboratory tests. We have searched the PubMed and Web of Science databases for biological variation and physiological rhythm articles in English without time restrictions with the terms "Biological variation, Within-subject biological variation, Between-subject biological variation, Physiological rhythms, Ultradian rhythms, Circadian rhythm, Infradian rhythms". It was concluded that, for effective management of predicting, preventing, and personalizing medicine, which is based on the safe and valid interpretation of patients' laboratory test results, both physiological rhythms and biological variation of the measurands should be considered simultaneously.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.