Evidence map›Paper›PMID 37047348›Full record

ArticleInternational journal of molecular sciences2023

miR-33a and Its Association with Lipid Profile in Patients with Carotid Atherosclerosis.

Marine M Tanashyan, Alla A Shabalina, Polina I Kuznetsova, Anton A Raskurazhev

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Marine M TanashyanResearch Center of Neurology, 80, Volokolamskoe Shosse, 125367 Moscow, Russia.
Alla A ShabalinaResearch Center of Neurology, 80, Volokolamskoe Shosse, 125367 Moscow, Russia.
Polina I KuznetsovaResearch Center of Neurology, 80, Volokolamskoe Shosse, 125367 Moscow, Russia.ORCID 0000-0002-4626-6520
Anton A RaskurazhevResearch Center of Neurology, 80, Volokolamskoe Shosse, 125367 Moscow, Russia.ORCID 0000-0003-0522-767X
Research Center of Neurology · RU

Funding

Russian Science Foundation №23-25-00477, https://rscf.ru/en/project/23-25-00477/
6 · The paper itself

Abstract

Atherosclerosis is a chronic inflammatory disease with a complex, multifactorial pathogenesis, which includes lipid metabolism alterations. miR-33a is a microRNA that plays a key role in cholesterol efflux and promotes atherosclerosis, yet its relationship with lipid markers in carotid atherosclerosis (CA) remains unclear. The objective is to evaluate possible associations between miR-33a expression and lipid biomarkers in patients with CA. This was a prospective study that included 61 patients (median age 66.0 years, 55.7% male) with evidence of CA. Lipid profile (total cholesterol, triglycerides [TG], high-density lipoprotein [HDL] and low-density lipoprotein [LDL] cholesterol) was analyzed. Extraction and quantification of miR-33a-5p/3p was performed according to protocol. Patients were further divided depending on the target LDL level (<1.8 mmol/L). Patients with CA had relatively favorable LDL levels with a median of 2.0 mmol/L. Both miR-33a-5p and miR-33a-3p levels were lower in patients with less than targeted LDL levels (37.4 and 38.3 vs. 41.8 and 42.5 respectively,

Indexed as

AtherosclerosisCarotid Artery DiseasesMicroRNAsAgedCholesterolCholesterol, LDLFemaleHumansMaleProspective StudiesCholesterolCholesterol, LDLMicroRNAscarotid atherosclerosischolesterollow-density lipoproteinmicroRNA

Identifiers

PMID37047348
PMCPMC10094421
OpenAlexW4361304616

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.