Evidence map›Paper›PMID 37047505›Full record

ArticleInternational journal of molecular sciences2023

Sitagliptin Mitigates Diabetic Nephropathy in a Rat Model of Streptozotocin-Induced Type 2 Diabetes: Possible Role of PTP1B/JAK-STAT Pathway.

Sarah M Al-Qabbaa, Samaher I Qaboli, Tahani K Alshammari, Maha A Alamin, Haya M Alrajeh, Lama A Almuthnabi, Rana R Alotaibi, Asma S Alonazi, Anfal F Bin Dayel, Nawal M Alrasheed and 1 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Ethyl Acetate Fractions ofInternational journal of molecular sciences · 2024
    Article
  10. Article
  11. Article
  12. Special Issue IJMS-Molecular Mechanisms of Diabetic Kidney Disease.International journal of molecular sciences · 2024
    Article
  13. Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Sarah M Al-QabbaaPharmD. Program, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
Samaher I QaboliPharmD. Program, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
Tahani K AlshammariDepartment of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.ORCID 0000-0002-2211-1014
Maha A AlaminDepartment of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.ORCID 0000-0002-4847-0840
Haya M AlrajehDepartment of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
Lama A AlmuthnabiPharmD. Program, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
Rana R AlotaibiPharmD. Program, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
Asma S AlonaziDepartment of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.ORCID 0000-0003-3367-002X
Anfal F Bin DayelDepartment of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.ORCID 0000-0002-7138-414X
Nawal M AlrasheedDepartment of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
Nouf M AlrasheedDepartment of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.ORCID 0000-0001-5283-1576
King Saud University · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetic nephropathy (DN) is a microvascular complication of diabetes mellitus. This study examined the therapeutic effects of sitagliptin, a dipeptidyl peptidase inhibitor, on DN and explored the underlying mechanism. Male Wistar albino rats (

Indexed as

Diabetes Mellitus, Type 2Diabetic NephropathiesAnimalsBiomarkersJanus KinasesMalePhosphoric Monoester HydrolasesRatsRats, WistarSignal TransductionSitagliptin PhosphateSTAT Transcription FactorsStreptozocinBiomarkersJanus KinasesPhosphoric Monoester HydrolasesSitagliptin PhosphateSTAT Transcription FactorsStreptozocindiabetic nephropathyinflammationJanus kinase/signal transducer activator of transcription pathwayprotein tyrosine phosphatase 1B

Identifiers

PMID37047505
PMCPMC10095069
OpenAlexW4362470996

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.